ArticleCurrent microbiology2025
Antibacterial Activity of Essential Oils from Clove and Elsholtzia Plants Against Common Pathogens of Bovine Mastitis, Antioxidant Activity, and Toxicity to Bovine Mammary Epithelial Cells.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Selection and Validation of qRT-PCR Reference Genes inCurrent issues in molecular biology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In light of concerns regarding milk quality deterioration and the rising threat of bacterial resistance, developing alternative treatments to antibiotics for mastitis has become imperative. Clove oil (CEO), a well-established natural antimicrobial, has not been extensively investigated for its synergistic potential when combined with Elsholtzia EO. Essential oils (EOs) from the plants were extracted using steam distillation. Gas chromatography-mass spectrometry (GC-MS) results showed that the main component of CEO was eugenol (76.59%), the main component of Elsholtzia densa EO was limonene (22.05%), the main component of Elsholtzia ciliata EO was carvone (31.63%), the main component of Elsholtzia fruticosa EO (EfEO) was eucalyptol (40.1%), and the main component of Elsholtzia stauntonii EO was cuminol (27.60%). Antimicrobial assays demonstrated CEO's superior efficacy against bovine mastitis pathogens (MIC: 1.875-7.5 mg/mL), while CEO/EfEO combination exhibited marked synergy (FICI ≤ 0.75). Further studies on the antimicrobial mechanisms of CEO, EfEO, and the CEO/EfEO combination showed that they were able to affect the integrity of the bacterial cell wall and increase membrane permeability. Such effect led to the leakage of biomolecules, including proteins and nucleic acids, accompanied by a concurrent decline in intracellular ATPase activity. The results of antioxidant activity assay showed that CEO exhibited stronger antioxidant capacity than EfEO. Cytotoxicity assessments conducted in bovine mammary epithelial cells delineated safe therapeutic windows, with EC
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Identifiers
40603548What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.