Evidence map›Paper›PMID 40603564›Full record

Reviewnpj metabolic health and disease2025

Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization.

Syed A H Zaidi, Ruth B Caldwell, Modesto A Rojas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in npj metabolic health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Syed A H Zaidi *Vascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Ruth B CaldwellVascular Biology Center, Augusta University, Augusta, GA, 30912, USA. rcaldwel@augusta.edu.
Modesto A Rojas *Vascular Biology Center, Augusta University, Augusta, GA, 30912, USA. mrojas@augusta.edu.

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Myeloid glycolysis in pathological ocular angiogenesisR01EY030500 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2019 to 2023
$2.6M
Adenosine receptor 2A in subretinal fibrosisR01EY033737 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Ruth B Caldwell, YUQING HUO · 2022 to 2026
$2.1M
"Myeloid PFKFB3 in subretinal fibrosis"R01EY033369 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2022 to 2025
$1.6M
Myeloid ACAT1 in ischemic retinopathyR01EY035683 · NEI · AUGUSTA UNIVERSITY · PI Ruth B Caldwell, Modesto Antonio Rojas · 2024 to 2026
$1.2M
Role of ACAT1 in Pathological Retinal NeovascularizationR21EY032265 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, ROJAS, MODESTO ANTONIO · 2021 to 2022
$418k
NEI NIH HHS 1R01EY035683-01NEI NIH HHS 5R21EY032265-02NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY030500NEI NIH HHS R01 EY033369NEI NIH HHS R01 EY033737NEI NIH HHS R01 EY035683NEI NIH HHS R21 EY032265
6 · The paper itself

Abstract

Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.

Identifiers

PMID40603564
PMCPMC12091695

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.