Evidence map›Paper›PMID 40603677›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

Recreational physical activity and health-related quality of life among breast cancer survivors: a systematic review.

Emma Tian, Oliver W A Wilson, Kaitlyn M Wojcik, Gisela Butera, Jacob Schneider, Laura Q Rogers, Wendy Demark-Wahnefried, Jinani Jayasekera

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emma TianDivision of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6594-4780
Oliver W A WilsonDivision of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0174-3813
Kaitlyn M WojcikDivision of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0004-7290-6343
Gisela ButeraOffice of Research Services, National Institutes of Health Library, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3976-0018
Jacob SchneiderDivision of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0009-6707-8674
Laura Q RogersDivision of General Internal Medicine and Population Science, Department of Medicine, Heersink School of Medicine at University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-4216-8381
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, School of Public Health at University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-5241-932X
Jinani JayasekeraDivision of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA. jinani.jayasekera@nih.gov.ORCID http://orcid.org/0000-0001-9212-7225

Funding

Health Equity and Decision SciencesZIAMD000022 · NIMHD · NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES · PI JAYASEKERA, JINANI · 2023 to 2025
$962k
Intramural NIH HHS ZIA MD000022NIMHD NIH HHS ZIA MD000022
6 · The paper itself

Abstract

purposeBreast cancer survivors are at increased risk of poor health-related quality of life (HRQOL). Clinical trials suggest physical activity interventions may improve HRQOL, however, evidence on whether these benefits extend to physical activity in real-world settings is limited. We aimed to evaluate the association between post-diagnosis recreational physical activity and HRQOL among breast cancer survivors in the observational literature and compare findings with clinical trial data.

methodsA systematic review was conducted, searching seven databases for studies published between January 2003 and October 2024. Study characteristics and adjusted analyses of the association between recreational physical activity and HRQOL were extracted. A qualitative synthesis categorized HRQOL outcomes into global, physical, emotional, social, and breast cancer-specific domains. Risk of bias was assessed, and findings from observational studies were compared with those from clinical trials.

resultsThe search identified 5831 sources, with 11 studies meeting inclusion criteria. For most domains, studies reported positive associations between aerobic activity and HRQOL. Meeting aerobic activity guidelines was found to have clinically meaningful positive associations with global HRQOL (Five studies), physical HRQOL (Two studies), and breast cancer-specific HRQOL (One study). Fewer studies reported on emotional/social domains of HRQOL or the association between muscle-strengthening activity and HRQOL. Overall, observational findings were consistent with clinical trial findings.

conclusionsObservational evidence suggests that aerobic activity guideline adherence may be associated with increased global and physical HRQOL. These findings indicate that benefits observed in trials may extend to real-world recreational aerobic activity. Further research is needed on muscle-strengthening activity and activity dosage.

Indexed as

Breast NeoplasmsCancer SurvivorsExerciseQuality of LifeRecreationAdultFemaleHumansMiddle AgedBreast cancer patientsExercisePatient reported outcomesWell-being

Identifiers

PMID40603677
PMCPMC12323690

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.