Evidence map›Paper›PMID 40603689›Full record

Articlenpj metabolic health and disease2024

The salivary metabolome of children and parental caregivers in a large-scale family environment study.

Jason A Rothman, Hillary L Piccerillo, Sage J B Dunham, Jenna L Riis, Douglas A Granger, Elizabeth A Thomas, Katrine L Whiteson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj metabolic health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jason A RothmanDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, 92697, USA. rothmanj@uci.edu.
Hillary L PiccerilloInstitute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, USA.
Sage J B DunhamDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Jenna L RiisInstitute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, USA.
Douglas A GrangerInstitute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, USA.
Elizabeth A ThomasInstitute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, USA.
Katrine L WhitesonDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, 92697, USA. katrine@uci.edu.

Funding

Temperment, Psychobiological, and Cognitive PredictorsP01HD039667 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLAIR, CLANCY B · 2002 to 2011
$29.1M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Early Life Stress and the Environmental Origins of Disease: a Population-based Prospective Longitudinal Study of Children in Rural PovertyUG3OD023332 · OD · NEW YORK UNIVERSITY · PI BLAIR, CLANCY B · 2016 to 2017
$6.5M
Cystic Fibrosis Foundation 003135F221Eunice Kennedy Shriver National Institute of Child Health and Human Development P01HD039667NIA NIH HHS AG00096-40NIA NIH HHS T32 AG000096NICHD NIH HHS P01 HD039667NIH HHS UG3 OD023332NIH Office of the Director 1UG3OD023332
6 · The paper itself

Abstract

Human metabolism is complex, and is impacted by genetics, cohabitation, diet, health, and environmental inputs. As such, we applied untargeted LC-MS metabolomics to 1425 saliva samples from a diverse group of elementary school-aged children and their caregivers collected during the Family Life Project, of which 1344 were paired into caregiver/child dyads. We compared metabolomes within and between homes, performed population-wide "metabotype" analyses, and measured associations between metabolites and salivary biomeasures of inflammation, antioxidant potential, environmental tobacco smoke (ETS) exposure, metabolic regulation, and heavy metals. Children and caregivers had similar salivary metabolomes, and dyad explained most metabolomic variation. Our data clustered into two groups, indicating that "metabotypes" exist across large populations. Lastly, several metabolites-putative oxidative damage-associated or pathological markers-were correlated with the above-mentioned salivary biomeasures and heavy metals. Implications of the family environment's effects on metabolomic variation at population, dyadic, and individual levels for human health are discussed.

Identifiers

PMID40603689
PMCPMC12118755

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.