Evidence map›Paper›PMID 40603718›Full record

ArticleEndocrine2025

Association between different response patterns during oral glucose tolerance test and postpartum glucose intolerance in women with gestational diabetes.

Jianing Bi, Li Zhang, Jing Peng, Yunshu Yang, Jing Jin, Qing Liu, Gaojie Fan, Qing Fang, Youjie Wang, Lulu Song and 1 more

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In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianing BiDepartment of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Li ZhangDepartment of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Jing PengDepartment of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Yunshu YangDepartment of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Jing JinDepartment of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Qing LiuDepartment of Maternal and Child Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Gaojie FanDepartment of Maternal and Child Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Qing FangDepartment of Maternal and Child Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Youjie WangDepartment of Maternal and Child Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lulu SongDepartment of Maternal and Child Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Guocheng LiuDepartment of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China. hnliuguocheng@126.com.

Funding

China Postdoctoral Science Foundation 2019M662646Guangzhou Science and technology planning project 202102080493Hubei Provincial Natural Science Foundation of China 2023AFB663National Natural Science Foundation of China 82003479the National Natural Science Foundation of China 82073660
6 · The paper itself

Abstract

purposeOur study aimed to assess the associations of the response patterns during gestational oral glucose tolerance test (OGTT) with postpartum glucose intolerance (PGI) in women with gestational diabetes mellitus (GDM).

methodsThis cohort study included 5348 GDM women who underwent the OGTT both 24-28 weeks during pregnancy and 4-12 weeks postpartum from January 2017 to June 2022. Gestational OGTT response patterns included individual time-point glucose values, glucose response trajectories, and GDM subtypes. PGI was defined as women with postpartum pre-diabetes or diabetes. Cox proportional hazards regression models were used to assess the risks of PGI according to different response patterns.

resultsDuring a median follow-up of 6.3 weeks post-delivery, 1727 (32.3%) women had PGI. Each time-point OGTT glucose were positively associated with PGI. Four OGTT glucose trajectories were fitted: 515 (9.6%) moderate increase following decrease, 557 (10.4%) sustained low-level increase, 3918 (73.3%) moderate increase following slow decrease, and 358 (6.7%) rapid increase following slow decrease. Compared with women with glucose moderate increase following decrease, those with rapid increase following slow decrease had the highest risk of PGI, followed by those with moderate increase following slow decrease. For GDM subtypes, 442 (8.3%) were isolated fasting hyperglycemia (IFH), 4227 (79.0%) were isolated post-load hyperglycemia (IPH), and 679 (12.7%) were combined hyperglycemia (CH). Compared with women with IFH, CH indicated the highest risk of PGI, followed by IPH.

conclusionsOur findings indicate that distinct OGTT response patterns are associated with varying risks of PGI in women with GDM.

Indexed as

Blood GlucoseDiabetes, GestationalGlucose IntolerancePostpartum PeriodAdultCohort StudiesFemaleGlucose Tolerance TestHumansPregnancyBlood GlucoseGestational diabetes mellitusPostpartum glucose intolerancePregnant women

Identifiers

PMID40603718

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.