Evidence map›Paper›PMID 40603787›Full record

ReviewAdvances in experimental medicine and biology2025

Control of Systemic Iron Homeostasis: Insights Gained from Studying Mouse Models.

Sandro Altamura, Martina U Muckenthaler

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TPC1-dependent control of endosomal pH and transferrin uptake determines cellular iron status.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sandro AltamuraCenter for Translational Biomedical Iron Research, Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany.
Martina U MuckenthalerCenter for Translational Biomedical Iron Research, Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany. martina.muckenthaler@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders of iron metabolism pose a global health challenge. Over the past two decades, novel regulators of systemic iron homeostasis have been identified that can be manipulated for therapeutic purposes. In this context, inbred and genetically modified mice have proven to be valuable tools enabling precise investigation of gene functions and testing of new pharmacological treatments that in some cases have reached the clinical stage. Here, we summarize the most recent discoveries on mechanisms regulating systemic iron homeostasis, with a specific focus on the role of murine models in advancing this research.

Indexed as

HomeostasisIronAnimalsDisease Models, AnimalHumansMiceIronBMP/SMAD signaling pathwayHepcidin-ferroportin axisIron metabolism disordersMurine models in iron regulationSystemic iron homeostasis

Identifiers

PMID40603787

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.