ArticleNature communications2025
Immature Acta2
Abstract read
In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Re-Purposing Sapropterin (Kuvan) for ACTA2-Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First-In-Human Therapeutic Report.Annals of clinical and translational neurology · 2026Article
- An Rnf213-deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling.Angiogenesis · 2026Article
- Molecular and multimodal biomarkers in Moyamoya disease: from pathogenic mechanisms to clinical translation.European journal of medical research · 2026Review
Corrections and comments
- Update of
Authors and funding
23 authors.
Anita Kaw *Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Suravi Majumder *Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jose E Esparza PineloDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8986-6959
Ting WuDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Zbigniew StarosolskiDepartment of Radiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Zhen ZhouDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Albert J PedrozaDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5291-5980
Xueyan DuanDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Kaveeta KawDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Angie D GonzalezDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ripon SarkarDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1393-6222
Michael P FischbeinDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Philip L LorenziMetabolomics Core Facility, Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0385-7774
Lin TanMetabolomics Core Facility, Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sara A MartinezMetabolomics Core Facility, Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4389-5604
Iqbal MahmudMetabolomics Core Facility, Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7729-8122
Laxman DevkotaDepartment of Radiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
L Maximilian BujaDepartment of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8386-7029
Heinrich TaegtmeyerDivision of Cardiovascular Medicine, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5434-6360
Ketan B GhaghadaDepartment of Radiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Sean P MarrelliDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Callie S KwartlerDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. Callie.S.Kwartler@uth.tmc.edu.ORCID http://orcid.org/0000-0002-3722-9939
Dianna M MilewiczDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. Dianna.M.Milewicz@uth.tmc.edu.ORCID http://orcid.org/0000-0002-7806-0068
Funding
Protocol Review and Monitoring SystemP30CA016672 · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1985 to 2025
$57.3MMarfan Aortic Embryologic Origin Influences Aneurysm FormationR01HL157949 · NHLBI · STANFORD UNIVERSITY · 2023 to 2025
$1.3MSWITCHING OF METABOLIC GENES IN UNLOADED HEARTR01HL061483 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1999 to 2004
$1.3MA novel nuclear role for smooth muscle alpha-actinR01HL175148 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2025 to 2025
$568kAmerican Heart Association (American Heart Association, Inc.) Merit AwardNCATS NIH HHS R03 TR004580NCATS NIH HHS TL1 TR003169NCATS NIH HHS UL1 TR003167NCI NIH HHS P30 CA016672NHLBI NIH HHS F32 HL154681NHLBI NIH HHS R01 HL061483NHLBI NIH HHS R01 HL109942NHLBI NIH HHS R01 HL146583NHLBI NIH HHS R01 HL157949NHLBI NIH HHS R01 HL175148NIH HHS S10 OD012304NIH HHS S10 OD030336U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) R03TR004580U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) TL1TR003169U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR003167U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL061483U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL109942U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL146583U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL157949U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL175148
Abstract
ACTA2 pathogenic variants altering arginine 179 cause childhood-onset strokes due to moyamoya disease (MMD)-like occlusions of the distal internal carotid arteries, but the mechanisms of pathogenesis are unknown and no preventive treatments exist. Here we show that Acta2
Indexed as
ActinsMoyamoya DiseaseMyocytes, Smooth MuscleOxidative PhosphorylationAnimalsCell DifferentiationCell MovementDisease Models, AnimalFemaleGlycolysisHumansMaleMiceMice, Inbred C57BLMitochondriaMuscle, Smooth, VascularActa2 protein, mouseActinsNiacinamide
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.