Evidence map›Paper›PMID 40604209›Full record

ArticleScientific reports2025

RNA-seq analysis identifies key genes and signaling pathways involved in androgen promotion of sebaceous gland proliferation in Hetian sheep.

Zhiya Feng, Zhigang Li, Wanwan Peng, Jianping Zhang, Chunyang Li, Ruijun Shi, Shuwei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhiya FengState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, 843300, China.
Zhigang LiCollage of Natural Resources and Environment, Northwest A&F University, Yangling, 712100, China.
Wanwan PengState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, 843300, China.
Jianping ZhangState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, 843300, China.
Chunyang LiState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, 843300, China.
Ruijun ShiState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, 843300, China. shiruijun2021@163.com.
Shuwei LiState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, 843300, China. yfzx_406@126.com.

Funding

Tarim University President's Fund TDZKBS202309Tianshan Talents - Leading Talent Cultivation Project for Technological Innovation 2023TSYCLJ0057
6 · The paper itself

Abstract

Sebaceous glands (SGs), essential elements of the skin barrier in sheep, are tightly regulated by the androgen signaling pathway. This study investigated how androgens influence SGs hyperplasia in sheep by combining morphological assessments with transcriptomic analysis. Histological examination revealed a significant increase (P < 0.05) in both the number and average size of SGs in the testosterone-treated groups across four concentration gradients compared to the control group. Transcriptome sequencing was performed on fifteen skin samples, revealing that, compared to the control group, 371 genes were upregulated and 115 were downregulated across the four treatment groups. The upregulated genes were predominantly enriched in lipid metabolism pathways, while the downregulated genes were mainly associated with keratin filament structures. Protein-protein interaction (PPI) network analysis identified ten hub genes involved in mitochondrial β-oxidation and lipid synthesis. These findings were further supported by gene set enrichment analysis (GSEA), which indicated significant activation of fatty acid metabolic pathways (P < 0.05). The results of this study suggest that androgens may be involved in SGs hyperplasia in sheep by regulating mitochondrial lipid metabolism-related pathways.

Indexed as

AndrogensSebaceous GlandsSignal TransductionAnimalsCell ProliferationGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksLipid MetabolismProtein Interaction MapsRNA-SeqSheepTestosteroneTranscriptomeAndrogensTestosteroneGSEAHetian sheepMasson stainingRNA-seqSkin

Identifiers

PMID40604209
PMCPMC12222945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.