ArticleNpj imaging2025
Spillover can limit accurate signal quantification in MPI.
Article in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Towards reliable tracking of natural killer cells using commercial iron oxide nanoparticles and magnetic particle imaging.Biomaterials science · 2026Article
- Systematic evaluation of magnetic particle imaging quantification strategies in biologically relevant scenarios using anatomically correct 3D printed mouse phantoms.Physics in medicine and biology · 2026Article
- Whole-body in vivo MPI cytometry reveals injection route-, dose-, cell size-, and disease-dependent differences in organ distribution.Science advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Accurate quantification of the magnetic particle imaging (MPI) signal in vivo remains a significant technical challenge. We assessed the "spillover effect", defined as leakage of signal from adjacent areas within a region of interest, within a field of view containing multiple hot spots, a scenario frequently encountered in vivo after systemic administration of a magnetic tracer. Using custom-designed phantom and in vivo mouse studies we determined the impact of fiducial positioning, iron content, and the iron concentration ratios within those hot spots, as well as the suitability of four different MPI scan modes for accurate signal quantification. Adjustment of the specific "target-to-fiducial distance (TFD)" and "target-to-fiducial Fe concentration ratios (TFCR)" significantly reduced the spillover effect. It's implementation to mitigate spillover effects will increase the accuracy of MPI for in vivo magnetic tracer quantification.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.