ArticleBMC microbiology2025
The effect of Akkermansia in patients with pregnancy induced hypertension.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsIntestinal dysbiosis in the second trimester is associated with pregnancy-induced hypertension (PIH) in the first trimester. However, the consequences and underlying mechanisms remain unclear.
methodsIn a follow-up cohort study, a nested case-control design was employed. Twenty healthy pregnant women in their second trimester were selected as controls, while nineteen patients with pregnancy-induced hypertension were included in the study. The 16 S rRNA sequencing was utilized to assess changes of gut microbiota patterns during early pregnancy. ELISA test was used to measure plasma inflammatory markers such as IL-1 beta, IL-6, TNF alpha, IL-8 and IL-10.
resultsThe PIH group exhibited lower microbial α-diversity compared to the healthy group. Although no statistically significant difference was observed at the genus level (p = 0.05), at the phylum level, the PIH patients showed a reduced abundance of Verrucomicrobia and an increased abundance of Firmicutes (p = 0.011). Donis analysis revealed that the Gut Microbiome Health Index (GMHI) of the PIH group was significantly worse than that of the control group. Additionally, Akkermansia abundance was significantly lower in the PIH group compared to the control group. Furthermore, more pro-inflammatory cytokines, such as IL-18 and capase-1, were produced in PIH plasma compared to the control group.
conclusionThe correlation analysis between gut microbiota and cytokines in PIH patients and controls revealed that Akkermansia was positively associated with IL-18 and capase-1 levels in PIH patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.