ArticleBMC plant biology2025
Integrated multi-omics reveals flavonoid-dominated defense strategies in Coptis chinensis under Fusarium root rot infection.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Physiological and Metabolomic Responses of 'Bluegold' Blueberry to Infection by an Isolate Preliminarily Identified asPlants (Basel, Switzerland) · 2026Article
- Transcriptomic and metabolomic analyses reveal the role of flavonoids in ectomycorrhizal symbiosis.Mycorrhiza · 2026Article
- Integrated analysis of endophytic fungal communities and metabolites reveals root rot-induced disruptions inFrontiers in plant science · 2026Article
- Flavonoids in Plants and Human Health: From Biosynthesis to Neurodevelopmental and Neurodegenerative Disorders.Molecules (Basel, Switzerland) · 2025Review
- Integrated Transcriptomic and Metabolomic Analyses Reveal Selenium Nanoparticle-Associated Alkaloid Accumulation in Stemona tuberosa Lour.Physiologia plantarumArticle
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Authors and funding
5 authors.
Funding
Abstract
Root rot disease poses a devastating threat to Coptis chinensis Franch, a medicinal plant prized for its bioactive alkaloids. To dissect its defense mechanisms, we conducted integrated transcriptomic and metabolomic analyses on resistant (R), early-stage infected (S-ES), and late-stage infected (S-LS) plants Our findings reveal a disease severity-dependent escalation in flavonoid metabolism. Key metabolites, such as kaempferol and quercetin derivatives, were significantly increased compared to R, paralleled by progressive upregulation of biosynthetic genes (PAL, CHS, CHI, FLS). Strikingly, salicylic acid (SA)-associated metabolites and pathway genes (NPR1, NPR3/NPR4) showed no differential expression across groups, contrasting with typical SA-mediated defenses in other species. This study uncovers flavonoid biosynthesis as the primary defense strategy in C. chinensis during root rot progression, while SA signaling may not be the main defense mechanism. These results provide actionable targets for enhancing disease resistance in medicinal plants through metabolic engineering.
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