Levels of peripheral CD4 + and CD8 + T cells and glycaemic control level in patients with both type 2 mellitus diabetes and stage III-IV periodontitis: a randomized controlled trial in Chinese population.

Yadan Fan, Zhikai Lin, Lan Cheng, Linhua Ge

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yadan FanDepartment of Periodontology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China.

Zhikai LinDepartment of Periodontology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China.

Lan ChengDepartment of Periodontology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China.

Linhua GeDepartment of Periodontology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China. lilyge2015@163.com.

Funding

Innovative Research Team of High-level Local Universities of Shanghai Jiao Tong University School of Medicine 2018 SSMU- ZDCX20180900National Natural Science Foundation of China 81991503Shanghai Clinical Research Center for Oral Diseases 19MC1910600Shanghai Municipal Key Clinical Specialty Shanghai Municipal Key Clinical Specialty

6 · The paper itself

Abstract

objectiveThe aim of this randomized controlled trial was to investigate the short-term glycated haemoglobin (HbA1c) level and proportional variation of peripheral T-lymphocytes status after subgingival scaling and root planing (SRP) therapy in patients with type 2 diabetes mellitus(T2DM) and stage III-IV periodontitis in Chinese population.

methodsFifty-one participants diagnosed T2DM and stage III-IV periodontitis were enrolled. Twenty-seven of them were randomly assigned to receive SRP + OHI treatment immediately and twenty-four only receive OHI and the delayed SRP treatment. Additionally, we divided participants into two stratifications according to initial HbA1c levels. The HbA1c values, proportion of peripheral CD4 + and CD8 + T-lymphocytes, CD4+/CD8 + ratio, and periodontal parameters: plaque index (PI), percentage of bleeding on probing (BOP%), pocket depth (PD) and clinical attachment level (CAL) were measured at baseline, 3 and 6 months.

resultsForty-eight participants completed the course of our study. At 6-month follow-up, the HbA1c reduction of SRP + OHI group is 0.22 ± 1.12%, greater than 0.07 ± 0.83% of OHI group(P = 0.592). When HbA1c ≥ 7.5%, the HbA1c reduction of SRP + OHI group is 0.74 ± 1.68%, comparing to 0.43 ± 0.91% of OHI group(P = 0.627); when HbA1c < 7.5%, the reductions were - 0.09 ± 0.39 and - 0.17 ± 0.70 respectively(P = 0.716). Both groups showed a slight decrease of peripheral CD4+/CD8 + ratio at 6-month revaluation. An 0.12 ± 0.08 increase of CD4+/CD8 + ratio was observed in SRP + OHI group when HbA1c ≥ 7.5%, which was significantly different to the conrol group(P = 0.040). As to periodontal parameters, PI, BOP% and PD were significantly improved after treatment, while the intergroup analysis in HbA1c ≥ 7.5% group showed no significant reduction of the PI and BOP% s at 6-months.

conclusionParticipants under hyperglycemia (HbA1c ≥ 7.5%) and stage III-IV periodontitis exhibited higher sensitivity of HbA1c level to SRP treatment. When HbA1c ≥ 7.5%, The peripheral CD4+/CD8 + ratio showed a slight increase in the intervention group while only reduction was found in other groups. And the peripheral CD4+/CD8 + ratio of SRP + OHI group in the HbA1c ≥ 7.5% stratification showed a significant increase while other subgroups all present a subtle decrease.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDiabetes Mellitus, Type 2Glycemic ControlPeriodontitisAdultChinaDental ScalingEast Asian PeopleFemaleGlycated HemoglobinHumansMaleMiddle AgedPeriodontal IndexRoot PlaningGlycated HemoglobinCD4+/CD8 + ratioPeriodontitisScaling and root planingType 2 diabetes

Identifiers

PMID40604671

DOI10.1186/s12903-025-06462-9

PMCPMC12224480

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.