ArticleBMC pulmonary medicine2025
Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Serum desmosine served as a biomarker for severity and prognosis in COVID-19 patients.BMC pulmonary medicine · 2026Article
- T Cell Activation Induces Synthesis of CD47 Proteoglycan Isoforms and Their Release in Extracellular Vesicles.International journal of molecular sciences · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
introductionSyndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However, there are few researches about the relation of serum syndecan-1 with corona virus disease 2019 (COVID-19).
methodsAll 235 COVID-19 patients were summoned. Serum samples and demographic characteristics were collected. Serum syndecan-1 level was determined by ELISA. The relationships of serum syndecan-1 with severity and prognosis were evaluated in COVID-19 patients through a prospective cohort study.
resultsOn admission, serum syndecan-1 level was raised in pace with COVID-19 severity scores. After treatment, serum syndecan-1 was decreased. Multivariate linear and logistic regression analyses revealed that higher age, coronary heart diseases, other chronic heart diseases, and SpO
conclusionThe serum syndecan-1 concentration is positively correlated with the severity and poor prognosis in COVID-19 patients. Syndecan-1 is a potential biomarker for the diagnosis and prognosis of COVID-19 in the future.
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