ArticleBMC oral health2025
Insulin resistance as a mediator between obesity and periodontitis risk.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Multi-omics integration reveals ANXA6-high γδ T cell-endothelial communication as a potential link between periodontitis and MASLD.NPJ systems biology and applications · 2026Article
- Periodontal severity and metabolic syndrome: A cross-sectional study from a tertiary care hospital in India.Bioinformation · 2026Article
- Joint association of triglyceride glucose index (TyG) and body roundness index with the risk of periodontitis: a cross-sectional study.Frontiers in nutrition · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundObesity is a well-established risk factor for periodontitis, a chronic inflammatory disease with systemic implications. While diabetes has been proposed as a potential mediator in this relationship, its clinical heterogeneity limits its utility in causal modeling. Insulin resistance, quantified by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), offers a more mechanistically grounded alternative.
objectivesThis study aimed to investigate the associations between obesity, insulin resistance, and periodontitis, with a specific focus on the mediating role of HOMA-IR.
methodsData from the National Health and Nutrition Examination Survey (NHANES, 2009-2012) including 8,473 participants were analyzed. Obesity was assessed using body mass index (BMI) and waist circumference (WC), and insulin resistance was measured using HOMA-IR. Periodontitis was evaluated using clinical attachment loss and probing depth. Multivariable logistic regression, restricted cubic splines, and mediation analyses were conducted.
resultsBoth BMI and WC were significantly associated with an increased risk of periodontitis (P < 0.05). HOMA-IR was positively associated with periodontitis risk (P < 0.01). Mediation analysis revealed that HOMA-IR mediated 63.44% of the association between BMI and periodontitis and 36.77% of that between WC and periodontitis. Nonlinear analyses showed no significant nonlinear trends.
conclusionsInsulin resistance, as reflected by HOMA-IR, plays a significant mediating role in the relationship between obesity and periodontitis. These findings underscore the importance of early metabolic regulation in mitigating obesity-related periodontal risk and provide mechanistic insight into the interplay between systemic and oral health.
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Registered trials
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