ArticleEuropean journal of medical research2025
Long non-coding RNA SNHG7 as a key driver of colorectal cancer proliferation and metastasis by inhibiting cuproptosis.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Role of Ferredoxin 1Cancer pathogenesis and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCopper-induced cell death, where copper induces cytotoxicity to kill cancer cells, exerts an unclear role in colorectal cancer. This study aimed to identify lncRNAs co-expressed with CICD-related genes and explore their effect on CRC.
methodsDifferentially expressed lncRNAs between CRC and normal samples were identified from public datasets, followed by co-expression analysis of 10 CICD-related genes. The prognostic lncRNA signatures were used to construct a prognostic model and validated by Kaplan-Meier and ROC curves. Clinical feature analysis and immune microenvironment assessment of identified lncRNAs were conducted, and in vitro assays were performed to validate their expression pattern and effect in CRC.
resultsFive lncRNAs co-expressed with CICD-related genes were identified, correlating with overall survival. The prognostic model showed that low-risk patients had better outcomes and higher CICD related gene expression, suggesting copper toxicity may eliminate CRC cells. Additionally, immune microenvironment analysis revealed that the low-risk group had higher immune cell infiltration along with upregulated immune checkpoint and HLA gene expression, indicating that CICD-related lncRNAs may influence CRC progression through immune microenvironment regulation. In vitro studies revealed the elevated levels of SNHG7 in CRC cells, and inhibiting SNHG7 suppressed CRC proliferation, migration, and invasion. SNHG7 downregulation also increased FDX1 expression, a key protein in the cuproptosis pathway.
conclusionsFive lncRNAs were identified as prognostic markers in CRC, with SNHG7 promoting CRC via a copper-dependent pathway. These findings provide insights for developing copper-targeted therapies for CRC patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.