Evidence map›Paper›PMID 40605100›Full record

SynthesisJournal of health, population, and nutrition2025

Impact of lifestyle factors and dietary patterns on serum uric acid levels and disease activity in gout: a systematic review.

Mohammad Mustafa, Shahad Alshamrani, Lama Alghamdi, Hala Danish, Dana Alamoudi, Ghala Alshamrani, Abdullah Alagha, Adnan Alshaikh, Saher Alqarni, Yasser Bawazir

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad MustafaDepartment of Medicine, University of Jeddah, Jeddah, Saudi Arabia. Mamustafa@uj.edu.sa.ORCID 0000-0003-0170-3747
Shahad AlshamraniMedical Student, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Lama AlghamdiMedical Student, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Hala DanishMedical Student, College of Medicine, King Saud Bin Abdulaziz for Health Sciences, Jeddah, Saudi Arabia.
Dana AlamoudiMedical Student, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Ghala AlshamraniMedical Student, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Abdullah AlaghaMedical Intern, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Adnan AlshaikhMedical Intern, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Saher AlqarniMedical Student, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Yasser BawazirMedical department, King Abdulaziz University, Jeddah, KSA, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGout is a common type of inflammatory arthritis caused by monosodium urate (MSU) crystal deposition in the joints. This leads to pain, swelling, and restricted motion. Although pharmacological treatments are effective, lifestyle and dietary factors play crucial roles in managing gout and its flares.

aimThis systematic review aimed to assess the effect of lifestyle factors, physical activity, and dietary patterns on serum uric acid levels and gout activity.

methodsA search of PubMed, BMJ journals, and Google Scholar identified eight studies (five prospective cohort studies, two case-cross-over studies, and one randomized controlled trial), involving 47,879 participants (predominantly males [78.5-95.3%], aged 55-66 years). Eligible studies focused on adults with gout and examined the lifestyle or dietary factors affecting uric acid levels or gout activity. The review followed a pre-specified protocol (PROSPERO registration CRD42024594359). To optimize the quality, the bias risk was assessed using the Newcastle-Ottawa scale for observational studies and the Cochrane Risk of Bias 1.0 tool for randomized controlled trials.

resultsThe findings suggest that consuming polyunsaturated fatty acid-rich fish, regular physical activity, and increased vegetable intake may reduce gout flares. Conversely, high purine intake (especially animal sources), excessive alcohol consumption, and obesity are risk factors for gout exacerbation. Some studies have reported reduced serum uric acid levels with dietary changes, whereas others have found no significant effect. Despite the variability and recall bias, dietary and lifestyle modifications may help manage gout and reduce disease activity.

conclusionThe findings of this systematic review emphasize the importance of dietary and lifestyle factors in managing serum uric acid levels and reducing the risk of gout flares. Further research is required to establish clinical recommendations to improve patient outcomes.

Indexed as

DietFeeding BehaviorGoutLife StyleUric AcidAgedExerciseFemaleHumansMaleMiddle AgedUric AcidArthritisDietary patternGoutLifestyle factorMNC infiltrationPhysical activityProspectiveSynovial membranesUric acids cohort study

Identifiers

PMID40605100
PMCPMC12225473

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.