ArticleMaterials today. Bio2025
Co-delivery paclitaxel and IR783 as nanoparticles for potentiated chemo-photothermal-immunotherapy of triple-negative breast cancer.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- New insights into breast cancer therapy: application and mechanisms of novel targeted nano-formulation.International journal of pharmaceutics: X · 2026Review
- Multidrug resistance in cancer: current understandings and future perspective.Molecular biomedicine · 2026Review
- pH-responsive CDs-based nanoplatform for chemo-resistant esophageal cancer treatment via downregulation of HIF-1α related pathway.Journal of nanobiotechnology · 2026Article
- Estrogen Receptor-Low Positive (ER-Low) Breast Cancer: A Unique Clinical and Pathological Entity.Current oncology (Toronto, Ont.) · 2026Review
- Exploring Anti-Neoplastic Activity of Chitosan Nanobubbles Decorated with ICOS-Fc and Loaded with Paclitaxel in a Human and Murine Model of Melanoma.Pharmaceutics · 2025Article
- Targeting the CXCR4/CXCL12 Axis to Overcome Drug Resistance in Triple-Negative Breast Cancer.Cells · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triple-negative breast cancer (TNBC) is highly malignant and invasive, which is the major challenge of breast cancer treatment. Although chemo-immunotherapy is currently the most promising treatment option, its efficacy in treating TNBC is limited due to challenges such as low immune response rate and severe side effects. In this study, a nanocarrier PEI-GCP(Z)/mPEG with excellent water solubility and high drug-loading capacity was designed, and it was used to load the paclitaxel (PTX) and photosensitizer IR783 to prepare nanoparticles PEI-GCP(Z)/mPEG@PTX@IR783 (PPI). The PPI demonstrated high loading efficiency for PTX and IR783, enabling the chemotherapy effect of PTX and the photothermal therapy under 808 nm laser irradiation, that combined chemotherapy and photothermal therapy. Furthermore, PPI could induce immunogenic cell death (ICD), promote dendritic cells (DCs) maturation, and increase the infiltration of cytotoxic T lymphocytes (CTLs) in the tumor site, thereby enhancing anti-tumor immunity. PPI also increased the proportion of effector memory T cells (Tem), thereby supporting long-term anti-tumor immunity. Both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.