ArticleFrontiers in microbiology2025
Multi-omics insights into key microorganisms and metabolites in Tibetan sheep's high-altitude adaptation.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Integrated Omics Analysis of the Effects of Nano-Antimicrobial Peptide on the Intestinal Microbiota and Metabolome of Tibetan Sheep.Animals : an open access journal from MDPI · 2026Article
- Comparative Hepatic Transcriptomic Analysis Reveals Metabolic Regulatory Differences Between Qilian and Oula Sheep.Veterinary sciences · 2026Article
- Appropriate Rumen-Protected Glutamine Supplementation During Late Gestation in Ewes Promotes Lamb Growth and Improves Maternal and Neonatal Metabolic, Immune and Microbiota Functions.Animals : an open access journal from MDPI · 2025Article
- Analysis of Gut Microbial Communities and Functions inMicroorganisms · 2025Article
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8 authors.
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Abstract
Tibetan sheep gastrointestinal microbial communities and metabolites showed adaptive differences with altitude, but we do not know which flora or metabolites may play an important role in acclimatization to the altitude environment. Therefore, we systematically analyzed the microbial structure and metabolites in the rumen and feces of Tibetan sheep at two altitudes (4,424 m and 2,364 m) using amplicon sequencing and untargeted metabolomics. The results showed that the bacterial communities differed greatly between the two groups, with high altitude Tibetan sheep having a higher forage fermentation capacity, and the abundance of some bacteria and fungi that were conducive to the decomposition of cellulose in rumen fluid increased significantly (especially Bacteroidota, Neocallimastigomycota, and Ascomycota), and the short chain fatty acids and NH
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