Evidence map›Paper›PMID 40606561›Full record

ArticlePhenomics (Cham, Switzerland)2025

Differences in Pathogenetic Mechanism Between Tibetan and Han High-Altitude Polycythemia Based on a Whole Genome-Wide Association Study.

Zhuoma Basang, Shixuan Zhang, Xianwei Ke, Zhuoma Duoji, La Yang, Danzeng Qiangba, Yang De, Deji Gesang, Zixin Hu, Yanyun Ma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phenomics (Cham, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. High-altitude polycythemia: State-of-the-art review.Therapeutic advances in hematology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhuoma Basang *High Altitude Health Science Research Centre of Tibet University, Tibet University, Lhasa, 850000 China.ORCID 0000-0003-3597-422X
Shixuan Zhang *State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438 China.
Xianwei Ke *Affiliated Hospital of Tibet University Lhasa, Fukang Hospital, Lhasa, 850000 China.
Zhuoma DuojiHigh Altitude Health Science Research Centre of Tibet University, Tibet University, Lhasa, 850000 China.
La YangHigh Altitude Health Science Research Centre of Tibet University, Tibet University, Lhasa, 850000 China.
Danzeng QiangbaHigh Altitude Health Science Research Centre of Tibet University, Tibet University, Lhasa, 850000 China.
Yang DeRehabilitation Medical Division, People's Hospital of Tibet Autonomous Region, Lhasa, 850000 China.
Deji GesangDivision of Rehabilitation Medicine of the People's Hospital of Tibet Autonomous Region, Lhasa, 850000 China.
Zixin HuArtificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, 200433 China.
Yanyun MaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438 China.
Meng HaoState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438 China.
Ruidong FanDepartment of Integrated Traditional Chinese and Western Medicine, Shigatse People's Hospital, Shigatse, 858701 China.
Li HanDepartment of Integrated Traditional Chinese and Western Medicine, Shigatse People's Hospital, Shigatse, 858701 China.
Zeshan LinState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438 China.
Yi LiState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438 China.
Jiucun WangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438 China.
Juan WuHigh Altitude Health Science Research Centre of Tibet University, Tibet University, Lhasa, 850000 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-altitude polycythemia (HAPC) is a prevalent chronic condition affecting individuals at high altitudes, including both highland and plains populations. This study, involving 2248 participants, explored genetic susceptibility to HAPC among ethnic groups, with 898 HAPC patients (450 Han, 448 Tibetan). The Genome-wide Association Study, encompassing 198 cases (100 Han, 98 Tibetan), identified eight Tibetan HAPC-susceptibility single-nucleotide polymorphisms and four in Han individuals. The common polymorphism locus rs7618658 ( Supplementary Information: The online version contains supplementary material available at 10.1007/s43657-024-00180-y.

Indexed as

Genome-wide association studyHigh-altitude polycythemiaIndependent verificationTibetan

Identifiers

PMID40606561
PMCPMC12209065

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.