Evidence map›Paper›PMID 40606913›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures.

Eyal Bar-Kochba, Catherine M Carneal, Vanessa D Alphonse, Andrea C Timm, Amanda W Ernlund, Carissa L Rodriguez, Itzy E Morales Pantoja, Lena Smirnova, Thomas Hartung, Andrew C Merkle

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eyal Bar-KochbaResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Catherine M CarnealResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Vanessa D AlphonseResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Andrea C TimmResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Amanda W ErnlundResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Carissa L RodriguezResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Itzy E Morales PantojaCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Lena SmirnovaCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Thomas HartungCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Andrew C MerkleResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Service members and law enforcement personnel are frequently exposed to blast overpressure during training and combat due to the use of heavy weaponry such as large-caliber rifles, explosives, and ordnance. The cumulative effects of these repeated low-level (<4 psi) blast exposures can lead to physical and cognitive deficits that are poorly understood. Brain organoids-human stem cell-derived three-dimensional

Indexed as

brain organoidsin vitro modellow-level blastprimary blastrepeated blasttraumatic brain injury

Identifiers

PMID40606913
PMCPMC12213761

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.