Evidence map›Paper›PMID 40607105›Full record

ArticlePNAS nexus2025

Morula complementation restores male germline in

Zachariah L McLean, Lisanne M Fermin, Sarah J Appleby, Jingwei Wei, Fanli Meng, Paul H Maclean, Benjamin J Perry, Brigid Brophy, Pavla Turner, Blaise Forrester-Gauntlett and 3 more

Abstract read
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Male germ cell technologies in large animals.The Journal of reproduction and development · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zachariah L McLeanAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.ORCID https://orcid.org/0000-0002-0968-0538
Lisanne M FerminAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.ORCID https://orcid.org/0000-0002-9773-8807
Sarah J ApplebyAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.ORCID https://orcid.org/0000-0002-5031-0694
Jingwei WeiAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.
Fanli MengAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.
Paul H MacleanStatistics, AgResearch, Grasslands Research Centre, Palmerston North 4410, New Zealand.ORCID https://orcid.org/0000-0001-8898-8276
Benjamin J PerryBioinformatics, Analytics and Modelling, AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.ORCID https://orcid.org/0000-0002-8272-1623
Brigid BrophyAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.ORCID https://orcid.org/0000-0003-1734-9359
Pavla TurnerAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.
Blaise Forrester-GauntlettAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.
David N WellsAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.ORCID https://orcid.org/0000-0002-8729-4958
Russell G SnellApplied Translational Research Group and Centre for Brain Research, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.ORCID https://orcid.org/0000-0002-8166-4014
Björn ObackAnimal Biotech, AgResearch Ltd, Ruakura Research Centre, Hamilton 3214, New Zealand.ORCID https://orcid.org/0000-0001-7279-4565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current livestock breeding is slow to respond to rapidly mounting environmental pressures that threaten sustainable animal protein production. New approaches can accelerate genetic improvement by multiplying valuable embryonic, rather than adult genotypes. Chimeras, derived from complementing a sterile host with a fertile donor embryo, provide a pathway to multiply and exclusively transmit elite male germlines. We established genetically sterile hosts and optimized embryo complementation conditions to achieve absolute germline transmission in sheep. The spermatogonia-specific gene

Indexed as

embryo complementationgermline chimeralivestockNANOS2spermatogonia

Identifiers

PMID40607105
PMCPMC12218192

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.