Evidence map›Paper›PMID 40607160›Full record

ArticleNeurobiology of sleep and circadian rhythms2025

Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation.

Abrar Al Maghribi, Caitlin Ottaway, Michael Rempe, Elizabeth Medina, Kaitlyn Ford, Kristan Singletary, Lucia Peixoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of sleep and circadian rhythms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abrar Al MaghribiDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Caitlin OttawayDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Michael RempeDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Elizabeth MedinaDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Kaitlyn FordDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Kristan SingletaryDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Lucia PeixotoDepartment of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.

Funding

The role of sleep on chromatin and transcriptional regulation across vertebrate evolution.R35GM147020 · NIGMS · WASHINGTON STATE UNIVERSITY · PI Lucia Peixoto · 2022 to 2026
$2.1M
UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODELF99NS135815 · NINDS · WASHINGTON STATE UNIVERSITY · PI MEDINA, ELIZABETH · 2023 to 2024
$98k
NIGMS NIH HHS R35 GM147020NINDS NIH HHS F99 NS135815
6 · The paper itself

Abstract

Rett syndrome (RTT) is a severe, progressive neurodevelopmental disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (

Indexed as

Mecp2Rett syndromeSleep architectureSleep deficits

Identifiers

PMID40607160
PMCPMC12219359

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.