Evidence map›Paper›PMID 40607249›Full record

ArticleInternational journal of biological sciences2025

Epithelial DPP4 promotes Ang II-driven renal fibrosis by targeting ACE2 activity in the renin-angiotensin system.

Yingying Zhang, Ruizhi Tan, Lehao Wu, Dan Zhao, Cheng Zhong, Chenggong Luo, Jeff Yat-Fai Chung, Patrick Ming-Kuen Tang, Chen Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingying ZhangDepartment of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Ruizhi TanResearch Center of Combined Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Lehao WuDepartment of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Dan ZhaoDepartment of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Cheng ZhongDepartment of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Chenggong LuoDepartment of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Jeff Yat-Fai ChungDepartment of Anatomical and Cellular Pathology, Peter Hung Pain Research Institute, Li Ka Shing Institute of Health Sciences, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong.
Patrick Ming-Kuen TangDepartment of Anatomical and Cellular Pathology, Peter Hung Pain Research Institute, Li Ka Shing Institute of Health Sciences, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong.
Chen YuDepartment of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal fibrosis is a characteristic of the progression of various chronic kidney diseases (CKD) to end-stage renal disease (ESRD). The renin-angiotensin system (RAS) is key to renal pathology. A better understanding of its regulatory mechanisms at the molecular level may lead to solutions for clinical CKD. Interestingly, our cohort study observed a positive correlation between epithelial dipeptidyl peptidase-IV (DPP4) levels and clinical CKD progression. Consistently, DPP4 was significantly increased in the unilateral ureteral obstruction (UUO) injured kidney

Indexed as

Angiotensin IIDipeptidyl Peptidase 4KidneyPeptidyl-Dipeptidase ARenin-Angiotensin SystemAngiotensin-Converting Enzyme 2AnimalsCell LineFibrosisHumansMaleMiceMice, Inbred C57BLRenal Insufficiency, ChronicACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Angiotensin IIDipeptidyl Peptidase 4DPP4 protein, humanPeptidyl-Dipeptidase ADipeptidyl peptidase-IVRenal fibrosisRenin-angiotensin system

Identifiers

PMID40607249
PMCPMC12210238

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.