Evidence map›Paper›PMID 40607659›Full record

ArticleAnimal genetics2025

Signatures of selection detected from whole-genome sequencing indicate that the small body size in dwarf rabbit breeds is caused by polygenic effects with a few major loci.

Samuele Bovo, Miguel Carneiro, Anisa Ribani, Matteo Bolner, Valeria Taurisano, Giuseppina Schiavo, Michele Schiavitto, Francesca Bertolini, Luca Fontanesi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuele BovoAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-5712-8211
Miguel CarneiroBIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal.ORCID https://orcid.org/0000-0001-9882-7775
Anisa RibaniAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-6778-1938
Matteo BolnerAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-4985-0191
Valeria TaurisanoAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-5349-1606
Giuseppina SchiavoAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-3497-1337
Michele SchiavittoAssociazione Nazionale Coniglicoltori Italiani (ANCI), Contrada Giancola Snc, Volturara Appula, Italy.ORCID https://orcid.org/0000-0002-9367-3823
Francesca BertoliniAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0003-4181-3895
Luca FontanesiAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-7050-3760

Funding

Italian Ministry of Agriculture, Food Sovereignty and Forestry - MASAFPortuguese Foundation for Science and Technology CEECINST/00014/2018/CP1512/CT0002Università di Bologna RFO2024
6 · The paper itself

Abstract

Early genetic studies have suggested that body size in rabbits can be considered a quantitative trait. Several rabbit breeds can be distinguished based on body size, including a few dwarf breeds differentiated by other morphological characteristics. While a large deletion in the HMGA2 gene is a major locus associated with dwarfism in Netherland Dwarf rabbits, it may not fully explain the reduced body size in this breed or other dwarf breeds. In this study, we compared the genomes of two dwarf rabbit breeds (Dwarf Lop and Netherland Dwarf) with those of non-dwarf rabbits by analysing whole-genome sequencing data obtained using a DNA-pool sequencing approach. We applied the fixation index (F

Indexed as

Body SizeDwarfismMultifactorial InheritanceSelection, GeneticAnimalsBreedingRabbitsWhole Genome SequencingDNA‐pool sequencingdwarfismOryctolagus cuniculuspolymorphismselection sweep

Identifiers

PMID40607659
PMCPMC12224565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.