Evidence map›Paper›PMID 40608154›Full record

ArticleHuman cell2025

CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia.

Yuan Yuan, Jiajia Li, Meng Wang, Yan Jin, Ruixiang Xia

Abstract read
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In one paragraph

Article in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuan YuanDepartment of Hematology, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China.
Jiajia LiDepartment of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, China.
Meng WangDepartment of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, China.
Yan JinDepartment of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, China.
Ruixiang XiaDepartment of Hematology, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. ruixiangxia@yeah.net.ORCID http://orcid.org/0009-0009-8199-0563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of circRNAs has been found to engage in the progression of many hematologic malignancies including acute myeloid leukemia (AML). In this study, we identified significantly downregulated circTADA2A, derived from linear transcriptional adaptor 2A (TADA2A) gene, in AML associated circRNAs microarrays using GEO2R tool. We aimed to elucidate the roles of circTADA2A in AML and the mechanisms involved. Quantitative reverse transcription PCR was used for verification of circTADA2A levels in AML specimens, and its diagnostic value and clinical significance were assessed. The effects of circTADA2A on proliferation and ferroptosis on THP-1 and HL-60 cells were carried out using cell counting kit-8, 5'-ethynyl-2'-deoxyuridine, Fe

Indexed as

Cell ProliferationFerroptosisLeukemia, Myeloid, AcuteMicroRNAsRNA, CircularDown-RegulationFemaleHL-60 CellsHumansMaleMicroRNAsMIRN638 microRNA, humanRNA, CircularAMLcircTADA2AFerroptosismiR-638Plasma

Identifiers

PMID40608154

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.