Evidence map›Paper›PMID 40608221›Full record

ArticleEJNMMI physics2025

Dosimetric study on radioembolization with 166Ho poly L-lactic acid microspheres: dead time effects on prediction power.

Bartolomeo Cassano, Ludovica Miseo, Sara Ungania, Marco D'Andrea, Federica Murtas, Massimiliano Pacilio, Marta Bottero, Daria Maccora, Rosa Sciuto, Giulio Eugenio Vallati and 2 more

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Article in EJNMMI physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bartolomeo CassanoDepartment of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Ludovica MiseoDepartment of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. ludovica.miseo@gmail.com.ORCID http://orcid.org/0000-0002-9038-599X
Sara UnganiaDepartment of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Marco D'AndreaDepartment of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Federica MurtasPost Graduation School of Medical Physics, Tor Vergata, Rome, Italy.
Massimiliano PacilioMedical Physics Department, AOU Policlinico Umberto I, Rome, Italy.
Marta BotteroRadiotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Daria MaccoraNuclear Medicine Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Rosa SciutoNuclear Medicine Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Giulio Eugenio VallatiInterventional Radiology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Antonella SorianiDepartment of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Giuseppe IaccarinoDepartment of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsA 1.9 GBq

resultsDT effects were significant for activity above 250 MBq (> 11.5%). Strong linear correlations between mean AD values in SA and TA were observed across methods. ΔD% between SA and TA for the liver contour was - 8.6% (M1), 21.5% (M2), and 8.2% (M3). For the HL contour, ΔD% was 8.1% (M1) and 39.0% (M2), while for the tumor contour, it was - 20.1% (M1) and 0.0% (M2). Gamma index pass rates for the liver contour were 76% (M1), 89% (M2), and 92% (M3); for the HL contour, 80% (M1) and 75% (M2); and for the tumor contour, 70% (M1) and 87% (M2).

conclusionDT significantly affects TA dose estimation, particularly in tumors. Proper DT correction improves the accuracy of dosimetric evaluation of

Indexed as

DosimetryHolmium-166 microspheresRadioembolization

Identifiers

PMID40608221
PMCPMC12229299

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.