SynthesisEpilepsia open2025
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in Epilepsia open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta-analysis of randomized controlled trials.Epilepsia open · 2025Pooled it
- Cognitive Side Effects of Antiseizure Medications in Adults with Epilepsy: An Update with a Focus on New Therapeutic Agents.CNS drugs · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of levetiracetam (LEV) compared to placebo in improving cognitive performance in people with cognitive decline. The protocol was pre-registered with PROSPERO (CRD420250656389) and reporting followed PRISMA guidelines. We searched RCTs that enrolled adult patients with cognitive decline, of any stage, comparing LEV to placebo or other active substance, and which reported at least one of the following primary or secondary outcomes: clinical dementia rating scale (CDR) or its sub-items; language, verbal memory/memory, executive, visuo-spatial and multi-domain cognitive test results. Studies were assessed for bias against the Cochrane Risk of Bias 2.0 tool. A meta-analysis was conducted using mean difference (MD) or standardized MD (SMD) according to the available scales. Meta-analysis of binary outcomes was used to compare adverse events. Overall, 6 RCTs provided data for 283 participants. LEV was not associated with a significant improvement in cognitive function measured by CDR-SB compared to placebo (MD = 0.04, 95% CI = -0.23 to 0.31, I
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.