Evidence map›Paper›PMID 40608405›Full record

ArticleeLife2025

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA.

Fabienne Maassen, Vu Thuy Khanh Le-Trilling, Luisa Betke, Thilo Bracht, Corinna Siegmund, Malte Bayer, Benjamin Katschinski, Antonia Belter, Tanja Becker, Denise Mennerich and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fabienne MaassenInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0009-0004-3535-3727
Vu Thuy Khanh Le-TrillingInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-2733-3732
Luisa BetkeInstitute for Experimental Cellular Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0009-0008-6767-6239
Thilo BrachtMedizinisches Proteom Center, Ruhr University Bochum, Bochum, Germany.
Corinna SiegmundInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-1371-0779
Malte BayerMedizinisches Proteom Center, Ruhr University Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0003-1060-8856
Benjamin KatschinskiInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-1314-2820
Antonia BelterInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0009-0005-4409-1447
Tanja BeckerInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Denise MennerichInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sebastian VoigtInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lori FrappierDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Barbara SitekMedizinisches Proteom Center, Ruhr University Bochum, Bochum, Germany.
Katharina FleischhauerInstitute for Experimental Cellular Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Mirko TrillingInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0003-3659-3541

Funding

Deutsche Forschungsgemeinschaft FL 843/1-1Deutsche Forschungsgemeinschaft TR 1208/1-1Deutsche Forschungsgemeinschaft TR 1208/2-1Deutsche Jose Carreras Leukämie Stiftung DJCLS 20R/2019
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a relevant pathogen, especially for individuals with impaired immunity. Harnessing potent immune antagonists, HCMV circumvents sterile immunity. Given that HCMV prevents the upregulation of

Indexed as

CD4-Positive T-LymphocytesCytomegalovirusHost-Pathogen InteractionsNuclear ProteinsTrans-ActivatorsViral ProteinsHumansMHC class II transactivator proteinNuclear ProteinsTrans-ActivatorsViral ProteinsCD4+ T cellsCD74CIITAGPCRG protein-coupled receptorHCMVHHV-5HLA class IIHLA-DPHLA-DRHuman cytomegalovirushuman herpesvirus 5infectious diseaselatencyM33microbiologyUS28viruses

Identifiers

PMID40608405
PMCPMC12226020

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.