Evidence map›Paper›PMID 40609320›Full record

ArticleDrug and alcohol dependence2025

The null effect of stress on cognitive flexibility in individuals with and without alcohol use disorder.

Erica N Grodin, Dylan E Kirsch, Steven Nieto, Malia Belnap, Yenashi Castillo, Nirvana Baker, Kate M Wassum, Kathleen A Grant, Lara A Ray

Abstract read
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In one paragraph

Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erica N GrodinDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Dylan E KirschDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA.
Steven NietoDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA.
Malia BelnapDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA; Neuroscience Interdepartmental Program, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Yenashi CastilloDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA.
Nirvana BakerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA.
Kate M WassumBrain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA; Neuroscience Interdepartmental Program, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Kathleen A GrantDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Lara A RayDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095 USA. Electronic address: lararay@psych.ucla.edu.

Funding

Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)T32HD091059 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mirella Dapretto, ANDREW J FULIGNI · 2018 to 2026
$1.7M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use DisorderK01AA029712 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Erica N Grodin · 2022 to 2026
$819k
The effects of stress on decision-making in alcohol use disorder: A translational approachR21AA030643 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2023 to 2024
$410k
A clinical neuroscience approach to understand stress coping in alcohol use disorderF32AA031425 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIRSCH, DYLAN E · 2024 to 2024
$32k
NIAAA NIH HHS F32 AA031425NIAAA NIH HHS K01 AA029712NIAAA NIH HHS K24 AA025704NIAAA NIH HHS R21 AA030643NICHD NIH HHS T32 HD091059
6 · The paper itself

Abstract

backgroundStress is a prominent motivator for drinking. Both stress and addiction are associated with impairments in cognitive flexibility. Preclinical work has explored the effect of stress on cognitive flexibility, but this has not been translated to clinical samples. Therefore, the present study tested whether acute stress decreased cognitive flexibility in individuals with and without AUD. It also explored if individuals with and without AUD recruit similar neurocircuitry during an acute stress provocation.

methodsSixty-five participants (AUD: N = 34; Control: N = 31) completed the Wisconsin Card Sorting Task at baseline, immediately prior to stress, and immediately following stress. Participants underwent the Montreal Imaging Stress Task during an fMRI scan to induce stress. Repeated measure ANCOVAs assessed the effects of stress, group, and stress X group interactions on ratings of stress and cognitive flexibility outcomes. Whole brain analyses examined group differences in the neural response to stress.

resultsBoth groups reported increases in subjective stress following the stress-induction task (p's < 0.04), but there were no stress X group interactions. There were no significant effects of stress, group, or stress X group interactions on cognitive flexibility measures (p's > 0.09). The control group had significantly greater activation in the anterior cingulate cortex during stress compared to individuals with AUD (p = 0.002).

conclusionsThere were no significant effects of acute stress on cognitive flexibility in individuals with or without AUD. However, individuals with AUD had lower anterior cingulate activation during acute stress compared to matched controls, possibly indicating that the control group recruited more top-down processing during stress.

Indexed as

AlcoholismCognitionExecutive FunctionStress, PsychologicalAdultBrainCognitive FlexibilityFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsYoung AdultAcute stressAlcohol use disorderAnterior cingulateCognitive flexibilityTop-down control

Identifiers

PMID40609320
PMCPMC12570523

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.