Evidence map›Paper›PMID 40610224›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Stress Sensitization of Neurons in the Dentate Gyrus Is Dependent on Neuronal Interleukin-1 Receptor Signaling and Is Associated with Increased Synaptic Plasticity, Perineuronal Nets, and Excitatory/Inhibitory Input Imbalance.

Ethan J Goodman, Riley M Britt, Fangli Zhao, Amara C Davis, Lynde M Wangler, Ethan Emami, Samuel P Swanson, Candice C Askwith, John F Sheridan, Jonathan P Godbout

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ethan J GoodmanDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Riley M BrittInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Fangli ZhaoDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Amara C DavisDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Lynde M WanglerDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Ethan EmamiInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Samuel P SwansonInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Candice C AskwithDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
John F SheridanInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, Ohio 43210.ORCID 0000-0002-6927-0266
Jonathan P GodboutDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210 sheridan.1@osu.edu jonathan.godbout@osumc.edu.

Funding

Social Defeat and Stress-Sensitization: Neuro-Immune Role of Spleen in Recurrence of AnxietyR56MH116670 · NIMH · OHIO STATE UNIVERSITY · PI GODBOUT, JONATHAN P, SHERIDAN, JOHN F · 2019 to 2020
$1.1M
Training Program in NeuroimmunologyT32NS105864 · NINDS · OHIO STATE UNIVERSITY · PI GODBOUT, JONATHAN P, POPOVICH, PHILLIP G · 2019 to 2023
$682k
NIMH NIH HHS R56 MH116670NINDS NIH HHS T32 NS105864
6 · The paper itself

Abstract

Repeated social defeat (RSD) in mice causes sensitization of hippocampal neurons associated with enhanced contextual fear memory. Because enhanced fear memory is an integral component of posttraumatic stress disorder, the physiological basis of neuronal sensitization in the hippocampus after social defeat was investigated in male mice using two interventions: microglia depletion (CSF1R antagonist, PLX5622) and neuronal (Vglut2

Indexed as

Dentate GyrusNerve NetNeuronal PlasticityNeuronsReceptors, Interleukin-1Stress, PsychologicalAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaSignal TransductionReceptors, Interleukin-1colony stimulatory factor-1 receptor antagonistelectrophysiologyhippocampusInterleukin (IL)-1 Receptor-1neuronsperineuronal netssensitizationsingle-nuclei RNA-seqstress

Identifiers

PMID40610224
PMCPMC12311764

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.