SynthesisSurgical endoscopy2025
Operative versus nonoperative treatment of acute cholecystitis during pregnancy: a systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Acute Cholecystitis in Pregnancy: A Review of Incidence, Risk Factors, Diagnostic Challenges, Management, and Maternal-Fetal Outcomes.Medicina (Kaunas, Lithuania) · 2026Review
- Complicated biliary disease during pregnancy: a retrospective cohort analysis from a tertiary care facility.Surgical endoscopy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute cholecystitis is the second most common non-obstetric abdominal emergency in pregnant women, with potential impact on both maternal and fetal outcomes. As the optimal treatment approach remains a subject of debate, we conducted this systematic review and meta-analysis to assess the safety of operative versus nonoperative treatment of acute cholecystitis during pregnancy.
methodsPubMed, Embase, and Cochrane Library databases were searched from inception to October 3, 2024. We conducted statistical analysis using Review Manager 5.4.1, employing a random-effects model to calculate the pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CIs) for dichotomous and continuous outcomes, respectively.
resultsWe included nine studies (45,883 pregnant women). Operative treatment significantly reduced the composite of adverse pregnancy outcomes (OR 0.60; 95% CI 0.42 to 0.87) and length of hospital stay (MD - 7.15; 95% CI - 7.83 to - 6.47) compared to nonoperative treatment. However, maternal mortality (OR 0.64; 95% CI 0.28 to 1.47), pregnancy loss (OR 1.21; 95% CI 0.66 to 2.22), preterm delivery (OR 0.64; 95% CI 0.32 to 1.30), and readmission rate (OR 0.15; 95% CI 0.02 to 1.03) were similar between the groups. In the sensitivity analysis, after the exclusion of the main source of heterogeneity, operative treatment was also associated with decreased preterm delivery and readmission rate.
conclusionCholecystectomy is associated with a significant reduction in adverse pregnancy outcomes and length of hospital stay and should be the treatment of choice for pregnant patients with acute cholecystitis.
Indexed as
Identifiers
40610639What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.