ArticleScientific reports2025
Impact of age on the homing potential of
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- NIS-Centered Reporter Gene Imaging and Radionuclide-Integrated Nanoplatforms for Quantitative Tracking of Immune Cell Therapy in Oncology and Inflammatory Disease Models.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
The ability of CD8 + T cells to protect against infections and malignant transformations declines with age. Emerging technologies, such as total body positron emission tomography (PET) and radiotracers with long half-lives, offer new approaches to assess long-term cellular functional deficits in vivo. In this study, we radiolabelled human CD8 + T cells from both young and old individuals with zirconium-89 (⁸⁹Zr) and evaluated their distribution in vivo. ⁸⁹Zr-labelled CD8 + T cells were injected intravenously into NOD scid gamma mice, and their whole-body migration was tracked using PET imaging. Longitudinal PET imaging revealed that CD8 + T cells from older individuals accumulated in tissues at a slower rate compared to those from younger individuals and may have caused greater tissue damage. This impaired migration was associated with decreased cortactin expression and increased cholesterol levels in aged T cells, both of which have the potential to hinder cellular motility. This study established a method for labelling and tracking cryopreserved CD8 + T cells, though further research is needed to understand the differences in migratory behaviour between cells from young and older individuals.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.