ArticleCommunications medicine2025
Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990-2021.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Association between the Glucose-to-Lymphocyte Ratio and Mortality in Patients with Ischemic Stroke: Based on the MIMIC-IV Database.Annals of Indian Academy of Neurology · 2026Article
- No Detectable Spatial Cognitive Impairment Despite Acute Sensorimotor Deficits Following Transient Middle Cerebral Artery Occlusion in Rats: A Post Hoc Exploratory Analysis.Brain and behavior · 2026Article
- Burden trajectories of stroke attributable to lipid-glucose dysfunction and biomarker validation: evidence from the global burden of disease (GBD) 2023 and the China health and retirement longitudinal study (CHARLS).Cardiovascular diabetology · 2026Article
- Machine learning versus deep learning for screening ischemic stroke among asymptomatic population.Scientific reports · 2026Article
- Neurochemical Mechanisms Underlying Tanshinone-Mediated Neuroprotection and Formulation Strategies in Cerebral Ischemia/Reperfusion Injury.Neurochemical research · 2026Review
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- Targeting Neuroinflammation in the Piriform Cortex-Amygdala: Enhanced Efficacy of Niosome-Based Sodium Butyrate in Ischemic Stroke.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- Spatiotemporal trends, demographic disparities, and predictions to 2040 in gastrointestinal cancer mortality in the United States.BMC public health · 2026Article
- Hemodynamic disturbances in vertebral artery dominance: a potential pathogenic mechanism in acute isolated pontine infarction.BMC neurology · 2026Article
- Inducing and monitoring photothrombotic stroke in anesthetic neuroprotection-free mice using functional photoacoustic microscopy.Neurophotonics · 2026Article
- Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management.MedComm · 2026Review
- [Analysis of disease burden, attributable risk factors of low back pain in China from 1990 to 2023 and prediction for 2030].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- The Mechanism of Ferroptosis and Blood-Brain Barrier Damage in Cerebrovascular Diseases.Biomedicines · 2026Review
- Antiphospholipid syndrome and pregnancy-a hematologic perspective.Research and practice in thrombosis and haemostasis · 2026Article
- Association of Serum Fetuin-B with Large-Artery Atherosclerotic Acute Ischemic Stroke and Functional Outcome.International journal of general medicine · 2026Article
- Acupuncture Activates PI3K/Akt Pathway to Promote Spinal Microglial M2 Polarization and Alleviate Spastic Hemiplegia Following Ischemic Stroke.Journal of inflammation research · 2026Article
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Authors and funding
16 authors.
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Abstract
backgroundVisualizing the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 and predicting future disease burdens at global, regional, and national levels can help health policymakers develop evidence-based ischemic stroke (IS) prevention and cure strategies.
methodsWe stratify epidemiological parameters by sex, age, the World Bank's classification of economies, and sociodemographic index (SDI) levels. We use frontier analysis to assess whether the burden of ischemic stroke (IS) in each country aligns with its level of economic development. We apply the Autoregressive Integrated Moving Average (ARIMA) model and the Bayesian age-period-cohort (BAPC) model to predict the burden of IS over the next 15 years.
resultsHere we show that IS accounts for 69.9 million prevalent cases, 7.8 million incident cases, 3.6 million deaths, and 70.4 million DALYs in 2021. In men, the global DALY rate of IS increases up to age 90-94 years and then decreases; however, for women, the rate increases up to the oldest age group (≥95 years). Regionally, we find that the association between the SDI and the age-standardized DALY rate of IS starts relatively flat, with a small peak up to a sociodemographic index of about 0.7, and then declines rapidly. Factors contributing most to the DALY rates for IS are high systolic blood pressure, high LDL cholesterol, and air pollution.
conclusionsThe disease burden of IS in medium-high SDI countries is still high, which means we could not meet the Sustainable Development Goal targets by 2030. Countries should formulate prevention and control measures suitable for their national conditions based on risk factors.
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Registered trials
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