ArticleExperimental & molecular medicine2025
Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia.
Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cellular Biological Basis and Novel Breakthroughs in the Pathogenesis of Myopia - A Narrative Review.International journal of general medicine · 2026Review
- Single-cell sequencing reveals reversible glial remodeling in the visual cortex during visual deprivation and recovery.Frontiers in immunology · 2026Article
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Authors and funding
16 authors.
Funding
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Abstract
Myopia is a serious public health issue worldwide. Damage to retinal ganglion cells (RGCs) in the retina induces degeneration of the visual cortex, which is known as anterograde trans-synaptic degeneration (TSD). However, the role of TSD in myopia is still unknown. Here single-cell RNA-sequencing revealed the activation of RGC apoptotic signals in the retinal ganglion and the remodeling of synapses in the visual cortex in myopia. The thickness of the retinal nerve fiber layer was negatively correlated with the degree of damage to the visual cortex and damage to neurons in the visual pathway and to the synaptic structure and function of the visual cortex indicated the occurrence of anterograde TSD in the visual pathway. The knockdown of Fos, which inhibited retinal neuronal apoptosis, suppressed TSD, indicating that myopia can aggravate RGC apoptosis, induce anterograde TSD and thus aggravate synaptic remodeling. Our findings provide a new experimental basis for understanding the pathogenesis of myopia.
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