ArticleBMC pulmonary medicine2025
Association of neutrophil percentage-to-albumin ratio with all-cause and respiratory disease-related mortality in US adults with asthma.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Synovial Fluid Biomarkers Reflect Pre- and Postoperative Clinical Features in Rotator Cuff Tears, Independent of Tear Size.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- The clinical usefulness of neutrophil percentage/albumin ratio in predicting the one-month mortality in chronic obstructive pulmonary disease patients hospitalized with community-acquired pneumonia.BMC pulmonary medicine · 2025Article
- Phenotypic Age Acceleration and Risk of All-Cause and Cardiovascular Mortality in US Adults With Asthma: A Retrospective Cohort Study.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundSystemic inflammation and immune dysregulation may be associated with asthma onset and progression. Neutrophil percentage-to-albumin ratio (NPAR) is a novel marker of systemic inflammation. We aimed to investigate the association of NPAR with all-cause and respiratory disease-related mortality in adults with asthma.
methodsThis is a retrospective cohort study using data from 5032 participants with asthma from the National Health and Nutrition (NHANES) spanning from 1999 to 2018. NPAR was calculated by neutrophil percentage (% of total white blood cell count) × 100/serum albumin (g/dl). Asthma was self-reported based on responses to a standardized questionnaire in NHANES. Mortality data were obtained through retrospective matching with the National Death Index (NDI), using secondary data from NHANES. Survey-weighted multivariable Cox proportional hazards regression analysis was used to explore these associations.
resultsAfter a median follow-up duration of 104 months, 696 participants died, of which 101 were respiratory disease-related deaths. In fully adjusted models, NPAR was significantly and positively associated with both all-cause and respiratory disease-related mortality (hazard ratios [HR] of 1.13 and 1.25, respectively, both p < 0.0001). Compared to Q1, NPAR at Q4 was associated with significantly increased all-cause and respiratory disease-related mortality (all-cause: HR 2.23, p < 0.0001; respiratory disease-related: HR 3.55, p = 0.004). NPAR was nonlinearly associated with all-cause mortality, with an inflection point of 13.76. This association was significant only after the inflection point (HR 1.18, p < 0.0001). The effect of NPAR on all-cause mortality was more pronounced in those < 60 years of age (HR 1.19, p < 0.0001).
conclusionsHigher NPAR was associated with increased all-cause and respiratory disease-related mortality in US adults with asthma. Further exploration of the prognostic potential and underlying mechanisms of NPAR is needed. CLINICAL TRIAL NUMBER: Not applicable.
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