← Diet, exercise & lifestyle × cardiovascular events

SynthesisHealth technology assessment (Winchester, England)2025

Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of RCTs.

Olalekan A Uthman et al.PubMed ↗Full text ↗Publisher ↗

  • Statinslooks good hereFewer composite cardiovascular events and deaths.Randomised, large.
  • Multifactorial lifestyle interventionslooks good hereFewer composite cardiovascular events and deaths.Randomised, large.

What the trial testedrandomised · 53,772 people · 2025

Randomised vs control (unspecified, implied as placebo or usual care)

Reduced composite cardiovascular events and deaths

−19%−29% to −9%

statins vs control (unspecified, implied as placebo or usual care)

Bigger than 4 in 10 for cardiovascular events

As reported

RR 0.81, 95% CI 0.71–0.91 · the paper's word: composite cardiovascular events and mortality

Randomised vs control (unspecified, implied as usual care or minimal intervention)

Reduced composite cardiovascular events and deaths

−25%−39% to −8%

multifactorial lifestyle interventions vs control (unspecified, implied as usual care or minimal intervention)

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.75, 95% CI 0.61–0.92 · the paper's word: composite cardiovascular events and mortality

Who was studied, and how

53,772people with cardiovascular disease, in this paper

The trial randomly assignedassigned by chance

statins
control (unspecified, implied as placebo or usual care)

Reduced composite cardiovascular events and deaths−19%

randomised

The trial randomly assignedassigned by chance

multifactorial lifestyle interventions
control (unspecified, implied as usual care or minimal intervention)

Reduced composite cardiovascular events and deaths−25%

randomised

the abstract, start to end

… 0.46 to 0.96), statins (risk ratio 0.81, 95% confidence interval 0.71 to 0.91) and multifactorial lifestyle interventions (risk ratio 0.75, 95% confidence interval 0.61 …

← favours treatmentfavours comparator →
could be chance
Composite cardiovascular events and mortalitystatins vs control (unspecified, implied as placebo or usual care)
RR 0.810.71–0.91
Composite cardiovascular events and mortalitymultifactorial lifestyle interventions vs control (unspecified, implied as usual care or minimal intervention)
RR 0.750.61–0.92
StatinsDiet, exercise & lifestyleCardiovascular events

Diet, exercise & lifestyle × cardiovascular eventshelps?one trial

unlikelylikely
0.50not counted

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted
← favours treatmentfavours comparator →
more certainless certain
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2 papers cite it

2025
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 40611785