ArticleBiophysics reports2025
Intracellular calcium imaging for agonist screening.
Article in Biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- CALHM5 deficiency alleviates aortic aneurysm by regulating smooth muscle calcium homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism.Nature communications · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium ions are involved in the regulation of a wide range of physiological activities such as nerve conduction, muscle contraction, cell division and gene expression through local calcium transients and global calcium oscillations. Calcium homeostasis modulator 1 (CALHM1) is a novel plasma membrane large-pore ion channel mediating calcium influx. Therefore, screening for novel CALHM1 agonists or antagonists is very important for the research of physiological and pathological processes and the development of therapeutic drugs for related diseases. In this protocol, we presented the detection of real-time calcium dynamics in transiently transfected cell lines and primary cells with genetically encoded calcium indicators or calcium indicator dyes, respectively. A comprehensive step-by-step approach has been outlined for drug screening and validation to offer a valuable guide for utilizing calcium imaging to investigate calcium-related physiological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.