Evidence map›Paper›PMID 40612388›Full record

ArticleSleep advances : a journal of the Sleep Research Society2025

An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype.

Cynthia Tchio, Jonathan S Williams, Herman Taylor, Hanna M Ollila, Richa Saxena

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. CircadianiScience · 2026
    Article
  2. Review
  3. bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Cynthia TchioCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jonathan S WilliamsDepartment of Medicine Endocrinology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Herman TaylorCardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Hanna M OllilaCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study Objectives: Chronotype, a manifestation of circadian rhythms, affects morning or evening preferences and ease of getting up. This study explores the genetic basis of morning chronotype and ease of getting up, focusing on the G-protein-coupled receptor locus, GPR61. Methods: We analyzed the genetic correlation between chronotype and ease of getting up using linkage disequilibrium score regression with summary statistics from the UK Biobank ( Results: We identified a strong genetic correlation (Rg = 0.80, Conclusions: Our findings reveal pleiotropic genetic factors influencing chronotype and ease of getting up, emphasizing

Indexed as

AMIGO1ATXN7L2circadian rhythmease of getting upgenetic pleiotropyGPR61knockout modelsmorning chronotypers12044778

Identifiers

PMID40612388
PMCPMC12224261

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.