ArticleInternational journal of general medicine2025
Utility of Serum Occludin as a Prognostic Biomarker of Severe Traumatic Brain Injury and Mediation Role of Acute Lung Injury: A Two-Center Prospective Cohort Study.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inorganic, Synthetic, Natural, and Innovative Hybrid Hydrogen Sulfide Donors and Inhibitors of Its Biosynthesis in the Treatment of Central and Peripheral Nervous System Injuries: A Systematic Analytical Review.International journal of molecular sciences · 2025Pooled it
- Potential Mechanisms of Tetramethylpyrazine in the Treatment of Traumatic Brain Injury Based on Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and in vivo Experiments.International journal of general medicine · 2025Article
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10 authors.
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Abstract
Background: Occludin is a crucial biomarker of blood-brain barrier disruption. Here, we investigated the association between serum occludin levels and poor neurological outcomes after severe traumatic brain injury (sTBI) and the mediating effect of acute lung injury (ALI). Methods: In this two-center prospective cohort study of 246 patients with sTBI and 100 controls, the serum occludin levels were measured. In-hospital ALI and six-month post-sTBI Glasgow Outcome Scale (GOS) scores were documented. Independent factorial relationships between severity and prognosis were determined. Results: Patients showed notably enhanced serum occludin levels compared to controls. Serum occludin levels were independently associated with Glasgow coma scale (GCS) scores, and Rotterdam computed tomography (CT) scores were linearly related to the likelihood of ALI and poor prognosis (GOS scores of 1-3), as well as independently associated with ALI, poor prognosis, ordinal GOS scores, and continuous GOS scores. The association of serum occludin levels with ALI and poor prognosis was not moderated by age, sex, hypertension, diabetes, alcohol consumption, or tobacco smoking. ALI partially mediates the relationship between serum occludin level and poor prognosis. As confirmed via a series of statistical approaches, prediction models of poor prognosis and ALI incorporating serum occludin levels and their respective independent predictors performed satisfactorily. Conclusion: A significant increase in serum occludin levels following sTBI is closely correlated with trauma severity, ALI, and poor prognosis. This may partially elucidate the link between serum occludin levels and poor prognosis, thereby strengthening serum occludin as an acceptable prognostic biomarker of sTBI.
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