Evidence map›Paper›PMID 40612872›Full record

ReviewOncology research2025

Clinically proven natural products against breast cancer, with mechanistic insights.

Md Mahmudul Hasan, Shah Md Wasin, Mishu Rahman, Eva Azme, Md Saqline Mostaq, Md Mahedi Hasan Nahid, Nor Mohammad, Farjana Afrin Tanjum, Md Anamul Haque, Md Ashiq Mahmud and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Acute and Subacute Oral Toxicity Evaluation ofFood science & nutrition · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Md Mahmudul HasanDepartment of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh.
Shah Md WasinDepartment of Natural Products and Pharmacology, Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh.
Mishu RahmanDepartment of Natural Products and Pharmacology, Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh.
Eva AzmeDepartment of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh.
Md Saqline MostaqSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Md Mahedi Hasan NahidDepartment of Pharmacy, University of Asia Pacific, Dhaka, 1205, Bangladesh.
Nor MohammadDepartment of Chemistry, University of Chittagong, Chattogram, 4331, Bangladesh.
Farjana Afrin TanjumBachelor of Medicine and Bachelor of Surgery, Chattogram Maa-o-Shishu Hospital Medical College, Agrabad, Chattogram, 4100, Bangladesh.
Md Anamul HaqueSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Md Ashiq MahmudSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Mohammad Nurul AminSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Breast cancer still stands to be the foremost contributor to cancer-related incidence and mortality in women globally accounting for about 14% of all female cancer-related deaths worldwide. This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment. Methodology: Required data for this review article was retrieved employing several readily obtainable search databases, including Web of Science Results: Several natural products, namely Omega-3 fatty acids, dietary isothiocyanates, curcumin, green tea, flaxseed, limonene, and others, were found to modulate crucial pathways in breast cancer cells. These substances suppressed angiogenesis by downregulating the vascular endothelial growth factor (VEGF), promoted apoptosis by activating caspase enzymes, and prevented cell proliferation by controlling cyclin-dependent kinases. Clinical studies demonstrated improved outcomes in patients receiving these natural products with standard treatment procedures. Discussion: The findings underscore the multifaceted functions of natural products in breast cancer therapy, highlighting their potential to increase the efficacy of conventional treatments while reducing adverse effects. Further exploration of synergistic actions and optimal dosages is needed. Conclusion: Clinically proven natural products represent a potential avenue for breast cancer treatment with their mechanistic insights that facilitate their incorporation into treatment regimens. To maximize clinical applications, future inquiries should center on elucidating the full spectrum of these anticancer functions.

Indexed as

Biological ProductsBreast NeoplasmsApoptosisFemaleHumansBiological ProductsBreast cancerChemotherapeutic potentialNatural products

Identifiers

PMID40612872
PMCPMC12215606

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.