ArticleDiabetes, obesity & metabolism2025
Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Understanding the socio-economic and health burden of obesity: a 10-year retrospective analysis of population-wide administrative healthcare data.Reviews in endocrine & metabolic disorders · 2026Review
- Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults: Standards of Care in Overweight and Obesity-2026.BMJ open diabetes research & care · 2026Review
- Body roundness index modified the association between sleep changes and multimorbidity in middle-aged and older adults: a nationwide cohort study.Journal of health, population, and nutrition · 2026Article
- Uncovering core diseases in temporal trajectories of cardiovascular-kidney-metabolic (CKM) syndrome in UK Biobank: network-based study.Scientific reports · 2026Article
- The combined effects of cardiometabolic index and high sensitivity C-reactive protein on cardiometabolic multimorbidity risk: a prospective analysis based on CHARLS.Lipids in health and disease · 2026Article
- Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.Diabetes, obesity & metabolism · 2025Article
- Evaluating and comparing the predictive ability with hypertension risk among obesity indicators: a prospective cohort integrating Mendelian randomization analysis.Frontiers in nutrition · 2025Article
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Authors and funding
10 authors.
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Abstract
backgroundOverweight and obesity are major risk factors for non-communicable diseases (NCDs). This study aimed to explore the pattern of multimorbidity development and disease trajectories in individuals with overweight and obesity.
methodsWe followed a cohort of 392 541 individuals retrospectively from the UK Biobank. This cohort included 131 075 with normal weight (BMI 18.5-24.9 kg/m
resultsDuring a median follow-up of 12.74 years, compared with individuals with normal weight, individuals with overweight had a higher risk of diagnosis of 17 NCDs, while those with obesity had 27. We identified 35 and 103 disease trajectories in individuals with overweight and obesity, among which, hypertension and cardiovascular diseases were key hub diseases. In particular, the age of disease diagnosis in individuals with obesity was younger than those with overweight, and the disease trajectory network in individuals with obesity was also 1.93 times more complex than overweight. Among identified disease trajectories, cardiometabolic diseases, including hypertension, coronary heart disease (CHD) and dyslipidemia, often appeared early, while heart failure and chronic kidney disease (CKD) appeared in a later stage of disease development. In women with obesity, depression diagnosis preceded most other multimorbidities and progressed to anxiety, painful conditions and CKD.
conclusionObesity can significantly contribute to a higher risk of multimorbidities at younger ages and with a more complex disease development trajectory than both normal weight and overweight populations. Early interventions for cardiometabolic diseases in individuals with overweight or obesity and depression in women with obesity are essential for multimorbidity management.
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