ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Estimating the impact of risk factor reduction on dementia prevalence in New Zealand.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Burden of Dementia in Europe, 1990-2023: a systematic analysis from the Global Burden of Disease Study 2023.The Lancet regional health. Europe · 2026Article
- The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions.The Lancet regional health. Western Pacific · 2026Article
- Estimating the impact of risk factor reduction on dementia prevalence in New Zealand.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
introductionWe aimed to estimate the prevention potential associated with a reduction in risk factor prevalence and the subsequent impact on dementia prevalence projections over time
methodsWe calculated potential impact fraction (PIF) of a 15% and 25% proportional reduction in risk factor prevalence for 12 modifiable dementia risk factors for New Zealand, and individually for the four main ethnic groups, then modeled this over a 30-year period.
resultsThe PIF for the total NZ population following a 15% risk factor reduction was 14.6% (95% confidence interval: 7.7-21.1) Modeled projections demonstrated prevalence reduction over time, from 1.0% at 10 years to 4.2% at 30 years. PIF and modeled reductions at all time points were higher for Māori and Pacific peoples. DISCUSSION: The projected impact of interventions targetting risk factor reduction increases over a 30-year time horizon and the benefit is potentially higher in ethnic groups with higher risk factor prevalence. HIGHLIGHTS: Achievable risk factor reductions have significant prevention potential. The projected impact of risk factor interventions increase with time. We need to consider longer time horizons when assessing proposed interventions.
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