SGLT2 inhibitors × glycemic control

SynthesisBiomolecules & biomedicine2025

Effectiveness of SGLT2 inhibitors compared to sulphonylureas for long-term glycemic control in type 2 diabetes: A meta-analysis.

Zhouhong Zhan et al.PubMed ↗Full text ↗Publisher ↗

  • SGLT2 inhibitorslooks good hereLower increases in HbA1c over time.Randomised, small.

What the trial testedrandomised · 2025

Randomised vs sulphonylureas (SUs)

Probably lowered increases in HbA1c over time

−0.28percentage points−0.35 to −0.20

SGLT2 inhibitors vs sulphonylureas (SUs)

As reported

difference −0.28 %, 95% CI −0.35 to −0.20

Randomised vs sulphonylureas (SUs)

Probably lowered increases in HbA1c over time

−0.11percentage points−0.19 to −0.04

SGLT2 inhibitors vs sulphonylureas (SUs)

As reported

difference −0.11 %, 95% CI −0.19 to −0.04

Randomised vs sulphonylureas (SUs)

Probably lowered increases in HbA1c over time

−0.12percentage points−0.25 to −0.01

SGLT2 inhibitors vs sulphonylureas (SUs)

As reported

difference −0.12 %, 95% CI −0.25 to −0.01

Who was studied, and how

people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

SGLT2 inhibitors
sulphonylureas (SUs)

Probably lowered increases in HbA1c over time−0.28

randomised

the abstract, start to end

weeks to 96-104 weeks, the pooled MD was -0.28% (95% CI: -0.35 to -0.20; p <

48-52 weeks to 96-104 weeks, the MD was -0.11% (95% CI: -0.19 to -0.04; p =

and from 104 weeks to 208 weeks (MD: -0.12%; 95% CI: -0.25 to -0.01; p =

← favours treatmentfavours comparator →
could be chance
Increases in HbA1c over timeSGLT2 inhibitors vs sulphonylureas (SUs)
−0.28−0.35 to −0.20
Increases in HbA1c over timeSGLT2 inhibitors vs sulphonylureas (SUs)
−0.11−0.19 to −0.04
Increases in HbA1c over timeSGLT2 inhibitors vs sulphonylureas (SUs)
−0.12−0.25 to −0.01
SGLT2 inhibitorsGlycemic control
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2025
2026
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Full record →Abstract, authors, funding and every citing paper · PMID 40613500