Evidence map›Paper›PMID 40613830›Full record

ArticleEJNMMI research2025

Model selection for dynamic PET compartmental modelling of

Hamed Moradi, Rajat Vashistha, Kieran O'Brien, Amanda Hammond, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh, David Reutens

Abstract read
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamed MoradiCentre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.
Rajat VashisthaCentre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.
Kieran O'BrienCentre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.
Amanda HammondARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia.
Axel RomingerDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, Bern, 3010, Switzerland.
Hasan SariDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, Bern, 3010, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, Bern, 3010, Switzerland.
Viktor VeghCentre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia. v.vegh@uq.edu.au.ORCID http://orcid.org/0000-0002-4310-1421
David ReutensCentre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.

Funding

Australian Research Council IC170100035
6 · The paper itself

Abstract

backgroundIn dynamic PET with tracer kinetic modeling, model complexity is an important but often under-recognised challenge affecting robust parameter estimation, particularly for noisy data. Traditional methods often neglect tissue heterogeneity and apply a single model universally. We applied a model selection approach alongside delay and motion correction, enabling the selection of models with varying complexity to better account for tissue heterogeneity.

resultsThe study included five subjects with breast cancer undergoing dynamic

conclusionsWe applied a standard model selection approach to identify the optimal compartmental model for voxel-wise parameter estimation in long field-of-view dynamic PET imaging. Our results demonstrate that accounting for tissue heterogeneity in breast lesions is critical for accurate quantification. Additionally, delay and motion correction were shown to improve image quality, enhance quantification accuracy, and support more reliable model selection. CLINICAL

trial registrationClinical trial number: not applicable.

Indexed as

Delay correctionDynamic PETLong field of view scannerModel selectionMotion correctionParametric mapping

Identifiers

PMID40613830
PMCPMC12227408

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.