Evidence map›Paper›PMID 40613872›Full record

ArticleCardiovascular intervention and therapeutics2025

Long-term outcomes of endovascular therapy for chronic limb-threatening ischemia patients with connective tissue disease.

Shohei Ouchi, Kao Takehisa, Naotaka Murata, Iwao Okai, Yuichi Chikata, Hirokazu Konishi, Masashi Nakao, Shinya Okazaki, Junichi Yamaguchi, Toru Minamino

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Cardiovascular intervention and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shohei OuchiDepartment of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.
Kao TakehisaDepartment of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan.
Naotaka MurataDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Iwao OkaiDepartment of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan. okaiwao@juntendo.ac.jp.
Yuichi ChikataDepartment of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.
Hirokazu KonishiDepartment of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.
Masashi NakaoDepartment of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan.
Shinya OkazakiDepartment of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.
Junichi YamaguchiDepartment of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan.
Toru MinaminoDepartment of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with connective tissue disease (CTD) and chronic limb-threatening ischemia (CLTI), revascularization is reported to be ineffective, with a poor prognosis and a high rate of lower-limb amputation. However, limited actual data are available. To study the long-term outcomes of endovascular therapy for CLTI patients with CTD, we established a multicenter registry (retrospective cohort study) in Japan. This study looked at major adverse extremity events, amputation-free survival, and all-cause mortality to better understand these rates. We registered 44 consecutive patients. The patients' mean age was 69.6 ± 11.4 years. There were 19 patients (43.2%) with diabetes, but only 4 patients (9.1%) were on dialysis. The average follow-up was 36.1 ± 31.7 months. In 11 patients (25.0%), the target wound healed without requiring lower-limb amputation. Target lesion revascularization occurred in 19 cases (43.2%), while unexpected minor amputations occurred in 11 cases (25.0%), major amputations in 8 cases (18.2%), and death in 15 cases (34.1%). The rates of freedom from major adverse extremity events at 1 and 3 years were 40.3% and 22.3%, respectively. The amputation-free survival rates were 69.3% at 1 year and 58.3% at 3 years. The survival rates were 85.5% at 1 year and 70.3% at 3 years. We conducted a multicenter study to look into the outcomes of CLTI patients with CTD who received endovascular therapy. Given the poor outcomes, more therapeutic advances for CLTI in CTD patients are needed.

Indexed as

Chronic Limb-Threatening IschemiaConnective Tissue DiseasesEndovascular ProceduresLower ExtremityAgedAmputation, SurgicalFemaleFollow-Up StudiesHumansJapanLimb SalvageMaleMiddle AgedRegistriesRetrospective StudiesTime FactorsAmputation-free survivalChronic limb-threatening ischemiaConnective tissue diseaseEndovascular therapyMajor adverse extremity events

Identifiers

PMID40613872

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.