Evidence map›Paper›PMID 40614007›Full record

ArticleHuman cell2025

Exosomes derived from human umbilical cord mesenchymal stem cells inhibit hepatocyte pyroptosis via miR-423-5p/ZBP1 in acute liver failure.

Dan Xie, Lina Yu, Ziyang Wang, Gongqin Qiu, Shi Ouyang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dan Xie *Guangzhou Key Laboratory of Enhanced Recovery After Abdominal Surgery, Department of Infectious and Liver Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510515, China.
Lina Yu *School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.
Ziyang WangSchool of Medicine, Hunan University of Medicine, Huaihua, 418099, China.
Gongqin QiuGuangzhou Key Laboratory of Enhanced Recovery After Abdominal Surgery, Department of Infectious and Liver Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510515, China.
Shi OuyangGuangzhou Key Laboratory of Enhanced Recovery After Abdominal Surgery, Department of Infectious and Liver Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510515, China. ouyangshi2005@163.com.

Funding

2022 Student innovation enhancement project 2024312257City school (college) enterprise joint funding 2023A03J0421Guangdong Basic and Applied Research Foundation iGandanF-1082023-RGG023Tertiary Education Scientific research project of Guangzhou Municipal Education Bureau 2023A1515220242
6 · The paper itself

Abstract

Human umbilical cord mesenchymal stromal cells (hucMSCs) have emerged as a promising therapeutic option for acute liver failure (ALF). However, the detailed mechanism by which hucMSCs modulate hepatocyte pyroptosis in ALF remains unclear. In this study, we induced ALF in mice using acetaminophen (APAP). Mice were intravenously injected with 1 × 10

Indexed as

ExosomesHepatocytesLiver Failure, AcuteMesenchymal Stem CellsMicroRNAsPhosphate-Binding ProteinsPyroptosisRNA-Binding ProteinsUmbilical CordAcetaminophenAnimalsCells, CulturedDisease Models, AnimalHumansMaleMiceAcetaminophenMicroRNAsPhosphate-Binding ProteinsRNA-Binding ProteinsAcute liver failureExosomeshucMSCsmiR-423-5pPyroptosis

Identifiers

PMID40614007
PMCPMC12227468

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.