Evidence map›Paper›PMID 40614019›Full record

ArticleJournal of magnetic resonance imaging : JMRI2025

Evaluation of Interstitial Fluid Volume and Diffusivity in Patients With Idiopathic Normal Pressure Hydrocephalus Using Spectral Diffusion Analysis.

Shota Ishida, Shigeki Yamada, Tatsuya Oki, Tomohiro Otani, Shinnosuke Hiratsuka, Shigeo Wada, Mitsuhito Mase, Yoshiyuki Watanabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shota IshidaDepartment of Radiological Technology, Faculty of Medical Science, Kyoto University of Medical Science, Nantan, Japan.ORCID https://orcid.org/0000-0002-0728-8057
Shigeki YamadaDepartment of Neurosurgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Tatsuya OkiDepartment of Radiology, Shiga University of Medical Science, Otsu, Japan.
Tomohiro OtaniDepartment of Mechanical Science and Bioengineering, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Japan.
Shinnosuke HiratsukaDepartment of Radiology, Shiga University of Medical Science, Otsu, Japan.
Shigeo WadaDepartment of Mechanical Science and Bioengineering, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Japan.
Mitsuhito MaseDepartment of Neurosurgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Yoshiyuki WatanabeDepartment of Radiology, Shiga University of Medical Science, Otsu, Japan.

Funding

Fujifilm CorporationJSPS KAKENHI 21K09098JSPS KAKENHI 22H00190JSPS KAKENHI 22H03020JSPS KAKENHI 24K02557JSPS KAKENHI 24K18778Outstanding Research Group Support Program in Nagoya City University 2401101Program for Promoting Researches on the Supercomputer Fugaku JPMXP1020230118
6 · The paper itself

Abstract

backgroundChanges in interstitial fluid (ISF) dynamics are potential contributors to idiopathic normal pressure hydrocephalus (iNPH). Spectral diffusion analysis provides surrogate markers for ISF volume (F PURPOSE: To compare F STUDY TYPE: Retrospective. POPULATION: 34 patients with iNPH (24 males, 10 females; 76.9 ± 7.6 years) and 132 HCs (46 males, 86 females; 47.5 ± 16.9 years; three age groups: < 40 years, 40-59 years, and ≥ 60 years). FIELD STRENGTH/SEQUENCE: 3.0 T/Single-shot spin-echo echo-planar imaging. ASSESSMENT: F STATISTICAL TESTS: Kruskal-Wallis test with Dunn's multiple comparison post hoc test. Spearman correlation coefficient. p < 0.05 was considered statistically significant.

resultsIn the CSO, iNPH DATA

conclusionSpectral diffusion analysis in iNPH demonstrated that ISF volume and diffusivity increased in PVH regions of the CSO and FWM, whereas ISF dynamics outside PVH regions may not differ significantly from those in HCs. EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 1.

Indexed as

Diffusion Magnetic Resonance ImagingExtracellular FluidHydrocephalus, Normal PressureAdultAgedAged, 80 and overBrainEcho-Planar ImagingFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedRetrospective StudiesWhite Matterdiffusion imagingglymphatic systemhakim diseaseidiopathic normal pressure hydrocephalusinterstitial fluidspectral analysis

Identifiers

PMID40614019
PMCPMC12435118

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.