ArticleScience advances2025
Integrating incompatible tandem photobiocatalysis in artificial cells enables metabolic modulation of natural cells.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Let There be Light! Light as an Engine and Regulator in Synthetic Cells.Angewandte Chemie (International ed. in English) · 2026Review
- Enhanced Enzyme Cascade Reactions Through Coencapsulation in Biocompatible Silica Nanoconfinement.Chembiochem : a European journal of chemical biology · 2026Article
- Cosurfactant-Induced Disorder in Polymersome Membrane Enhances Diffusion of Cargo Molecules.ACS nano · 2026Article
- Bioactive Artificial Cells as Autonomous Metabolic Actuators Enable Bidirectional Communication with Tumor Cells.Journal of the American Chemical Society · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sustaining biological reactions in artificial cells is crucial for their practical integration into living systems, which relies on continuous cofactor supply. Although photocatalysis enables cofactor regeneration in synthetic biological systems, the generated reactive oxygen can deactivate enzymes. Here, we engineer photobiocatalytic artificial cells that modulate hepatocyte metabolism through alleviating alcohol-induced oxidative stress. These artificial cells feature nano-organelles that segregate incompatible modules: one for photocatalytic cofactor regeneration and another for biocatalytic alcohol metabolism. This spatial separation ensures sustainable cofactor provision and protects enzymes from oxidative damage. Co-compartmentalization of alcohol dehydrogenase and aldehyde dehydrogenase within a single nano-organelle enhances cascade reaction efficiency while inhibiting intermediate leakage. When cocultured with hepatocytes, these artificial cells demonstrate excellent biocompatibility and efficiently mitigate oxidative stress from alcohol metabolism. This work advances artificial cells from proof of concept to practical application in living systems. The successful connection of photocatalysis and enzymatic reactions broadens the range of strategies available for chemical synthesis, synthetic biology, and biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.