Evidence mapPaperPMID 40614745Full record

ReviewLancet (London, England)2025

Scientific advances in the assessment, modification, and generation of transplantable organs for patients with end-stage organ diseases.

Ciara M Shaver, Peter P Reese, Adam Griesemer, Andreas Zuckermann, Matthew Bacchetta

Abstract readReview
In one paragraph

Review in Lancet (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ciara M ShaverDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Transplant Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Peter P ReeseVanderbilt Center for Transplant Science, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: peter.reese@vumc.org.
Adam GriesemerNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Andreas ZuckermannDepartment of Cardiac and Thoracic Aortic Surgery, Medical University of Vienna, Vienna, Austria.
Matthew BacchettaDepartment of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.

Funding

Immunogenomic analysis of donor lung injury and its impact on clinical outcomes after lung transplantationR01HL160551 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$730k
NHLBI NIH HHS R01 HL160551
6 · The paper itself

Abstract

The large deficit in donated organs required to provide transplantation to patients with end-stage organ disease is a global health crisis, exacerbated by regional differences in clinical practice and available resources. This deficit highlights the need for better tools to determine organ suitability for transplantation and to enhance the recovery of potential donor organs which are currently not transplanted due to concerns about organ quality. Novel organ assessment approaches, including epidemiological predictive models, advanced functional biometrics, and refined histological analysis, show potential to better identify donated organs suitable for transplantation. In addition, novel machine perfusion platforms have shown remarkable capacities to preserve and potentially modify injured organs, and a series of xenotransplantation experiments suggest a viable pathway to create a new organ supply. Collectively, these technologies will gradually alleviate the organ shortage and expand access to life-saving transplants.

Indexed as

Organ TransplantationTissue and Organ ProcurementHumansTissue DonorsTransplantation, Heterologous

Identifiers

PMID40614745
PMCPMC13274895

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.