Evidence map›Paper›PMID 40615895›Full record

ArticleActa neuropathologica communications2025

Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model.

Noriko Okuno, Seiji Yamamoto, Takeru Hamashima, Tung Son Dang, Naruho Okita, Miwa Fujikawa, Tomomi Kunisawa, Nobuyuki Takakura, Toshihiko Fujimori, Hisashi Mori and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Noriko OkunoDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Seiji YamamotoDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan. seiyama@med.u-toyama.ac.jp.
Takeru HamashimaDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Tung Son DangDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Naruho OkitaDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Miwa FujikawaDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Tomomi KunisawaDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Nobuyuki TakakuraDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, 565-0871, Japan.
Toshihiko FujimoriDivision of Embryology, National Institute for Basic Biology, Okazaki, 444-8787, Japan.
Hisashi MoriDepartment of Molecular Neuroscience, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Christer BetsholtzDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 75185, Sweden.
Katsuyoshi TakataDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Masakiyo SasaharaDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan. sasahara@med.u-toyama.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many neurological diseases remain difficult to treat, necessitating further elucidation of their pathogenesis. Conditional inactivation of Pdgfra in Nestin-expressing cells leads to the depletion of platelet-derived growth factor receptor-alpha

Indexed as

BrainCerebral CortexDemyelinating DiseasesFibroblastsInflammationMacrophagesPia MaterAnimalsDisease Models, AnimalMeningesMiceMice, Inbred C57BLMice, TransgenicNestinReceptor, Platelet-Derived Growth Factor alphaNestinReceptor, Platelet-Derived Growth Factor alphaAngiogenesisBorder-associated macrophageFibrosisMyelination failurePDGFRαPerivascular fibroblast

Identifiers

PMID40615895
PMCPMC12226894

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.